Huang Donghai, Qiu Yuanzheng, Li Guo, Liu Chao, She Li, Zhang Diekuo, Chen Xiyu, Zhu Gangcai, Zhang Xin, Tian Yongquan, Liu Yong
Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha 410008, Hunan, China.
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Xiangya Road 87, Changsha 410008, Hunan, China.
J Cancer. 2018 Jan 1;9(1):198-204. doi: 10.7150/jca.22145. eCollection 2018.
Lysine demethylase (KDM) 5B, as a member of the histone lysine demethylase family, is overexpressed and functions abnormally in various human cancers. However, its expression in the squamous cell carcinoma of the head and neck (SCCHN) remains unclear. KDM5B expression was analyzed by immunohistochemistry and correlated with clinicopathological parameters in 103 archival SCCHN tissue samples and 24 adjacent noncancerous epithelial tissues. We found that KDM5B expression was higher in SCCHN than that in adjacent noncancerous tissues. This was closely associated with lymph node metastasis and tumor recurrence. In addition, Kaplan-Meier analysis revealed that patients with high KDM5B expression had shorter disease-free and overall survival times than those with low KDM5B expression. Importantly, both univariate and multivariate analysis demonstrated that KDM5B level was an independent prognostic factor in SCCHN patients. These results indicate that KDM5B is a valuable biomarker that can be used to predict SCCHN patient outcome.
赖氨酸去甲基化酶（KDM）5B作为组蛋白赖氨酸去甲基化酶家族的一员，在多种人类癌症中过度表达且功能异常。然而，其在头颈部鳞状细胞癌（SCCHN）中的表达仍不清楚。通过免疫组织化学分析了103份存档的SCCHN组织样本和24份相邻的非癌上皮组织中KDM5B的表达，并将其与临床病理参数相关联。我们发现，SCCHN中KDM5B的表达高于相邻的非癌组织。这与淋巴结转移和肿瘤复发密切相关。此外，Kaplan-Meier分析显示，KDM5B高表达的患者无病生存期和总生存期比KDM5B低表达的患者短。重要的是，单因素和多因素分析均表明，KDM5B水平是SCCHN患者的独立预后因素。这些结果表明，KDM5B是一种有价值的生物标志物，可用于预测SCCHN患者的预后。
