State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China; University of Chinese Academy of Science, Beijing 100049, PR China.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China; Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China.
Colloids Surf B Biointerfaces. 2018 Mar 1;163:175-183. doi: 10.1016/j.colsurfb.2017.12.045. Epub 2017 Dec 26.
It is important to fabricate an implant possessing environment sensitive drug delivery. In this work, the construction of 3D porous structure on polyetheretherketone (PEEK) surface and pH sensitive polymer, chitosan, was introduced. The smart release of doxorubicin can be realized on the 3D porous surface of PEEK loading chitosan. We give a feasible explanation for the effect of chitosan on smart drug release according to Henderson-Hasselbalch equation. Furthermore, the intracellular drug content of the cell cultured on the samples with highest chitosan is significantly higher at pH 4.0, whereas lower at pH 7.4 than other samples. The smart release of doxorubicin via modification with chitosan onto 3D porous PEEK surface paves the way for the application of PEEK in drug loading platform for recovering bone defect caused by malignant bone tumor.
制备具有环境敏感药物输送功能的植入物非常重要。在这项工作中，我们在聚醚醚酮（PEEK）表面引入了 3D 多孔结构和 pH 敏感聚合物壳聚糖。通过在 PEEK 负载壳聚糖的 3D 多孔表面上，可以实现阿霉素的智能释放。根据 Henderson-Hasselbalch 方程，我们对壳聚糖对智能药物释放的影响给出了合理的解释。此外，在 pH 值为 4.0 时，细胞在壳聚糖含量最高的样品上的细胞内药物含量显著高于其他样品，而在 pH 值为 7.4 时则低于其他样品。通过将壳聚糖修饰到 3D 多孔 PEEK 表面上来实现阿霉素的智能释放，为 PEEK 在用于恶性骨肿瘤引起的骨缺损修复的药物载体平台中的应用铺平了道路。
