Sun Yingxiao, Liu Xingdan, Tan Ji, Lv Dan, Song Wengang, Su Rui, Li Ling, Liu Xuanyong, Ouyang Liping, Liao Yun
Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Changning District, Shanghai 200050, China.
Regen Biomater. 2020 Nov 28;8(1):rbaa043. doi: 10.1093/rb/rbaa043. eCollection 2021 Feb 1.
Polyetheretherketone (PEEK) has been used as an implant material because it has similar mechanical properties to natural bone. However, inferior osseointegration and bioinertness hamper the clinical application of PEEK. In this study, the surfaces of sulfonated three-dimensional (3D) PEEK porous structures were loaded with different concentrations of strontium ranelate, a compound commonly used in the treatment or prevention of osteoporosis by promoting bone formation and inhibiting bone resorption. Field-emission scanning electron microscopy was used to characterize the topography of the structures, elemental carbon, oxygen and strontium contents were measured by X-ray photoelectron spectroscopy, and surface zeta potentials and water-contact angle were also measured. The results indicated that strontium ranelate was successfully loaded onto the 3D porous structures. cellular results showed that strontium ranelate-treated sulfonated PEEK (SP-SR) strengthened the adhesion of MC3T3-E1 cells. The activity of alkaline phosphatase, collagen secretion and extracellular matrix mineralization deposition of MC3T3-E1 cells were also improved on the surface of SP-SR. These results indicate that SP-SR could serve a new implant candidate for surgical treatment.
聚醚醚酮（PEEK）因其机械性能与天然骨相似而被用作植入材料。然而，较差的骨整合能力和生物惰性阻碍了PEEK的临床应用。在本研究中，磺化三维（3D）PEEK多孔结构表面负载了不同浓度的雷奈酸锶，雷奈酸锶是一种常用于治疗或预防骨质疏松症的化合物，可促进骨形成并抑制骨吸收。采用场发射扫描电子显微镜对结构形貌进行表征，通过X射线光电子能谱测量元素碳、氧和锶的含量，并测量表面zeta电位和水接触角。结果表明，雷奈酸锶成功负载到3D多孔结构上。细胞实验结果表明，雷奈酸锶处理的磺化PEEK（SP-SR）增强了MC3T3-E1细胞的黏附。在SP-SR表面，MC3T3-E1细胞的碱性磷酸酶活性、胶原蛋白分泌和细胞外基质矿化沉积也得到了改善。这些结果表明，SP-SR可作为外科治疗的新型植入候选材料。
