Lee Joo-Hyeon, Rawlins Emma L
Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Physiology, Development and Neurobiology, University of Cambridge, Cambridge, UK.
Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, UK; Department of Pathology, University of Cambridge, Cambridge, UK.
Dev Biol. 2018 Jan 15;433(2):166-176. doi: 10.1016/j.ydbio.2017.09.016. Epub 2017 Dec 25.
Chronic degenerative lung diseases are essentially untreatable pathological conditions. By contrast, the healthy lung has numerous mechanisms that allow for rapid repair and restoration of function following minor acute injuries. We discuss the normal endogenous processes of lung development, homeostatic maintenance and repair and consider the research strategies required for the development of methods for human therapeutic lung regeneration.
慢性退行性肺病本质上是无法治疗的病理状况。相比之下，健康的肺有许多机制，可在轻微急性损伤后实现快速修复和功能恢复。我们讨论肺发育、稳态维持和修复的正常内源性过程，并思考开发人类治疗性肺再生方法所需的研究策略。
