Grote J J, Bakker D, Hesseling S C, van Blitterswijk C A
Ear, Nose and Throat Department, University Hospital, Leiden, The Netherlands.
Acta Otolaryngol. 1989 Mar-Apr;107(3-4):225-34. doi: 10.3109/00016488909127502.
In response to a Staphylococcus aureus-induced middle ear infection the tympanic membrane showed infiltration of polymorphonuclear granulocytes, lymphocytes, and macrophages and increased areas covered by ciliary and secretory epithelium. These reactions, which were comparable to the cellular and mucociliary responses seen in the middle ear mucosa during infection, were restricted to the pars flaccida and to predominantly the annular and manubrial regions of the pars tensa. This showed that the greater part of the tympanic membrane, where the lamina propria is composed of collagenous bundles and only very thin layers of loose connective tissue, is hardly affected by or barely responds to the inflammatory stimulus.
针对金黄色葡萄球菌引起的中耳感染，鼓膜显示出多形核粒细胞、淋巴细胞和巨噬细胞浸润，以及被纤毛和分泌上皮覆盖的面积增加。这些反应与感染期间中耳黏膜中所见的细胞和黏液纤毛反应相当，仅限于松弛部，主要是紧张部的环形和柄部区域。这表明，鼓膜的大部分区域，其固有层由胶原束和非常薄的疏松结缔组织层组成，几乎不受炎症刺激的影响或几乎不响应炎症刺激。
