Bakker D, van Blitterswijk C A, Hesseling S C, Daems W T, Grote J J
Ear, Nose & Throat Department, University Hospital, The Netherlands.
J Biomed Mater Res. 1990 Jul;24(7):809-28. doi: 10.1002/jbm.820240703.
Epithelial reactions to Silastic, Estane polyether urethane, polypropylene oxide, and a poly(ethylene oxide hydantoin) and poly(tetramethylene terephthalate) segmented polyether polyester copolymer were investigated after implantation in tympanic membranes and submucosa of noninfected and Staphylococcus aureus-infected rat middle ears. Porous implants made of Estane and polypropylene oxide were completely covered by tympanic-membrane connective tissue, epidermis, and epithelium in 2 weeks and those made of copolymer in between 2 and 4 weeks postoperatively. Silastic implants, which were dense, were not enveloped by tympanic-membrane tissue but rejected. Starting in the 6th postoperative month the proliferative activity and structure of both the tympanic membrane epithelium and epidermis became normal except for the presence of iron-containing secretory epithelium near polypropylene oxide. After initial swelling caused by the surgical trauma, neither the proliferative activity nor the composition of the epithelium covering submucosal implants was affected by the presence of any of the biomaterials. Infection of middle ears bearing implants induced epithelial reactions similar to those associated with infected middle ears without an implant.
在将硅橡胶、依斯特兰聚醚聚氨酯、聚环氧丙烷、聚（乙内酰脲环氧乙烷）和聚对苯二甲酸丁二醇酯嵌段聚醚聚酯共聚物植入未感染和金黄色葡萄球菌感染的大鼠中耳鼓膜及黏膜下层后，研究了上皮对它们的反应。由依斯特兰和聚环氧丙烷制成的多孔植入物在术后2周被鼓膜结缔组织、表皮和上皮完全覆盖，而由共聚物制成的植入物在术后2至4周被完全覆盖。致密的硅橡胶植入物未被鼓膜组织包裹而是被排斥。术后第6个月起，除了聚环氧丙烷附近存在含铁分泌上皮外，鼓膜上皮和表皮的增殖活性及结构恢复正常。在手术创伤引起的初始肿胀之后，覆盖黏膜下植入物的上皮的增殖活性和组成均未受到任何生物材料的影响。植入物所在中耳的感染引发的上皮反应与未植入物的感染中耳相关反应相似。
