Grote J J, van Blitterswijk C A
Acta Otolaryngol. 1984 Sep-Oct;98(3-4):239-49. doi: 10.3109/00016488409107560.
This paper describes an investigation performed to study the middle ear events ensuing from Staphylococcus aureus induced infection in the middle ear cavity of the rat. To obtain an evaluation at both the cell and the tissue level, scanning electron microscopy, transmission electron microscopy and histology were used. Staphylococcus aureus infection appears to be characterized by five major events: (i) cellular response, (ii) humoral response, (iii) mucociliary response, (iv) fibroblastic response, (v) bony response. Since these occurrences correspond to the events witnessed in the human middle ear affected by acute otitis media, S. aureus achieved infection might prove a useful tool for the further study of this disease, by means of animal experiments.
本文描述了一项研究，旨在探究大鼠中耳腔内金黄色葡萄球菌感染引发的中耳病变。为了在细胞和组织层面进行评估，采用了扫描电子显微镜、透射电子显微镜和组织学方法。金黄色葡萄球菌感染似乎具有五个主要特征：（i）细胞反应，（ii）体液反应，（iii）黏液纤毛反应，（iv）成纤维细胞反应，（v）骨质反应。由于这些情况与人类急性中耳炎患者中耳所观察到的病变相对应，通过动物实验，金黄色葡萄球菌感染可能成为进一步研究该疾病的有用工具。
