Bakker D, van Blitterswijk C A, Hesseling S C, Daems W T, Kuijpers W, Grote J J
Ear, Nose, & Throat Department, University Hospital, Leiden, The Netherlands.
J Biomed Mater Res. 1990 Jun;24(6):669-88. doi: 10.1002/jbm.820240604.
The biocompatibility of dense Silastic implants and porous implants made of Estane 5714 F1 polyether urethane, polypropylene oxide, and an HPOE/PBT segmented polyether polyester copolymer was evaluated during an induced Staphylococcus aureus middle ear infection. The middle ear response to infection seemed not to be affected by the presence of implants made of either of the polymers. Light microscopical morphometry and transmission electron microscopy showed degradation of the porous implants under study, but not of Silastic implants, which were invariably surrounded by a fibrous capsule. This finding, combined with the degree of porous implant degradation, the composition of the tissues surrounding the implants, and the tissue/biomaterial interface reactions are consistent with the results obtained in the noninfected middle ear. Round-cell infiltrates however, were predominantly associated with implants made of polypropylene oxide and HPOE/PBT copolymer; while the presence of (phagocytosed) microbial debris was associated with copolymer. The present findings indicate that with respect to implant behavior in infected surroundings Estane is the best porous material, whereas the behavior of Silastic implants did not deviate from that in non-infected ears.
在诱导的金黄色葡萄球菌中耳感染期间，评估了致密硅橡胶植入物以及由Estane 5714 F1聚醚聚氨酯、聚环氧丙烷和HPOE/PBT嵌段聚醚聚酯共聚物制成的多孔植入物的生物相容性。中耳对感染的反应似乎不受任何一种聚合物制成的植入物的影响。光学显微镜形态计量学和透射电子显微镜显示，所研究的多孔植入物有降解，但硅橡胶植入物没有降解，硅橡胶植入物总是被纤维囊包围。这一发现，结合多孔植入物的降解程度、植入物周围组织的组成以及组织/生物材料界面反应，与在未感染中耳中获得的结果一致。然而，圆形细胞浸润主要与聚环氧丙烷和HPOE/PBT共聚物制成的植入物有关；而（吞噬的）微生物碎片的存在与共聚物有关。目前的研究结果表明，就植入物在感染环境中的行为而言，Estane是最好的多孔材料，而硅橡胶植入物的行为与未感染耳朵中的行为没有偏差。
