Department of Physics, Isfahan University of Technology, Isfahan 84156-83111, Iran.
Institute of Science and Technology (IST) Austria, 3400 Klosterneuburg, Austria.
Front Biosci (Landmark Ed). 2018 Mar 1;23(8):1391-1406. doi: 10.2741/4651.
In this paper, we discuss biological effects of electromagnetic (EM) fields in the context of cancer biology. In particular, we review the nanomechanical properties of microtubules (MTs), the latter being one of the most successful targets for cancer therapy. We propose an investigation on the coupling of electromagnetic radiation to mechanical vibrations of MTs as an important basis for biological and medical applications. In our opinion, optomechanical methods can accurately monitor and control the mechanical properties of isolated MTs in a liquid environment. Consequently, studying nanomechanical properties of MTs may give useful information for future applications to diagnostic and therapeutic technologies involving non-invasive externally applied physical fields. For example, electromagnetic fields or high intensity ultrasound can be used therapeutically avoiding harmful side effects of chemotherapeutic agents or classical radiation therapy.
本文讨论了电磁场在癌症生物学中的生物学效应。特别是,我们回顾了微管的纳米力学特性,后者是癌症治疗最成功的靶点之一。我们提出了对电磁辐射与微管机械振动耦合的研究,作为生物和医学应用的重要基础。我们认为,光机械方法可以在液体环境中精确地监测和控制分离的微管的机械性能。因此,研究微管的纳米力学特性可能为未来涉及非侵入性外部施加物理场的诊断和治疗技术的应用提供有用信息。例如,电磁场或高强度超声可用于治疗,避免化学治疗剂或经典放射疗法的有害副作用。