Feng D, Yao T, Cheng Y P, Pan M H, Li C X, Wang J, Feng Y L, Shi J, Huang H L, Lu H Y, Lan G H, Wang S P, Zhang Y W
Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.
Ningming County Center for Disease Control and Prevention of Guangxi Zhuang Autonomous Regional, Ningming 532500, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Dec 10;38(12):1624-1628. doi: 10.3760/cma.j.issn.0254-6450.2017.12.008.
To reveal the prevalence and the related factors of hepatitis B (HepB) virus infection among HIV/AIDS patients. We conducted a cross-sectional study in two HIV clinics, affiliated to local Centers of Disease Control and Prevention in Guangxi Zhuang Autonomous Regional. A face-to-face interview, with questionnaire was conducted to collect information on socio-demographic characteristics, drug use, and sexual behavior. Blood samples were used to test HBsAg. (2) test or Fisher's exact test and unconditional logistic regression models were used to identify the influencing factors. The prevalence of HBV and HIV co-infection was 13.85% (113/816). Results from multivariate logistic regression analyses showed that age (25-45), family history of HBV and history of HepB vaccination were independent influencing factors for HBV and HIV coinfection, with (95%) as 1.738 (1.031-2.931), 2.898 (1.678-5.005) and 1.744 (1.052-2.892), respectively. The prevalence of HBV among HIV/AIDS patients was significantly higher than that in general population. HIV/AIDS patients aged between 25 and 45 and with family history of HBV were more likely to be infected with HBV, while HepB vaccination was associated with the reduction of HIV/HBV coinfection. Specific comprehensive prevention and treatment programs on HIV/AIDS patients need to be set up.
为揭示艾滋病病毒/艾滋病(HIV/AIDS)患者中乙型肝炎(HepB)病毒感染的流行情况及相关因素。我们在广西壮族自治区当地疾病预防控制中心下属的两家HIV门诊进行了一项横断面研究。通过面对面访谈并采用问卷收集社会人口学特征、吸毒情况和性行为等信息。采集血样检测乙肝表面抗原(HBsAg)。采用卡方检验或Fisher精确检验以及非条件logistic回归模型来确定影响因素。HBV与HIV合并感染的患病率为13.85%(113/816)。多因素logistic回归分析结果显示,年龄(25 - 45岁)、乙肝家族史和乙肝疫苗接种史是HBV与HIV合并感染的独立影响因素,其比值比(95%置信区间)分别为1.738(1.031 - 2.931)、2.898(1.678 - 5.005)和1.744(1.052 - 2.892)。HIV/AIDS患者中HBV的患病率显著高于一般人群。年龄在25至45岁且有乙肝家族史的HIV/AIDS患者更易感染HBV,而乙肝疫苗接种与降低HIV/HBV合并感染有关。需要针对HIV/AIDS患者制定具体的综合防治方案。