Nielsen Morten, Hansen Christian R, Brink Carsten, Bertelsen Anders S, Kristiansen Charlotte, Stefan S Jeppesen, Hansen Olfred
Laboratory of Radiation Physics, Odense University Hospital, 29 Sdr. Boulevard, DK-5000 Odense C, Denmark.
Department of Clinical Research, University of Southern Denmark, 19 Winsløwparken, DK-5000 Odense C, Denmark.
J Radiosurg SBRT. 2016;4(2):153-161.
Flattening filter free (FFF) high dose rate beam technique was introduced for brain stereotactic radiosurgery (SRS) and lung Stereotactic Body Radiotherapy (SBRT). Furthermore, a HexaPOD treatment table was introduced for the brain SRS to enable correction of rotational setup errors. 19 filter flattened (FF) and 57 FFF brain SRS treatments, as well as 451 FF and 294 FFF lung SBRT treatments were evaluated to assess differences in intrafractional motion (IFM) between FF and FFF treatments. For brain SRS the accuracy of rotational corrections was assessed as well. For SRS the treatment time was reduced by 21%, and for SBRT the treatment time was reduced by 25%. However, only for SBRT the IFM was significantly reduced, from 1.9 mm to 1.6 mm. For brain SRS, table correction in 6D greatly improves patient setup precision observed as a reduction in mean residual rotational setup error from 0.3° (SD1.2°) to 0.06° (SD 0.3°).
无均整器（FFF）高剂量率射束技术被引入用于脑部立体定向放射外科手术（SRS）和肺部立体定向体部放射治疗（SBRT）。此外，为脑部SRS引入了六轴机器人治疗床，以校正旋转摆位误差。对19例均整滤过（FF）和57例FFF脑部SRS治疗，以及451例FF和294例FFF肺部SBRT治疗进行评估，以评估FF和FFF治疗之间的分次内运动（IFM）差异。对于脑部SRS，还评估了旋转校正的准确性。对于SRS，治疗时间减少了21%，对于SBRT，治疗时间减少了25%。然而，仅对于SBRT，IFM显著降低，从1.9毫米降至1.6毫米。对于脑部SRS，六维床校正极大地提高了患者摆位精度，平均残余旋转摆位误差从0.3°（标准差1.2°）降至0.06°（标准差0.3°）。
