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侧卧位接受放射外科治疗的脊柱肿瘤患者的可行性:纪念斯隆凯特琳癌症中心的病例系列

Feasibility of radiosurgery for patients with spinal tumors treated in lateral decubitus position: A case series from Memorial Sloan Kettering Cancer Center.

作者信息

Navo Elliot B, Lovelock D Michael, Zatcky Joan, Yamada Josh

机构信息

Southern Ohio Medical Center, 1121 Kinney's Lane, Portsmouth, OH 45662, USA.

Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

出版信息

J Radiosurg SBRT. 2017;4(4):315-323.

Abstract

INTRODUCTION

Often in clinical practice radiation oncologists encounter patients who require treatment to the spine commonly in the setting of metastatic disease. These metastases usually cause pain, immobility, or neurologic deficits mandating expedited therapy to alleviate the suffering of our patients. Spine radiosurgery techniques have been used extensively for palliation purposes; however, given the patients' deteriorating condition or pain and inability to tolerate anesthesia the radiation oncologist is often left with the conundrum of how to best set up his or her patient in preparation for radiosurgery if supine is not a viable option. In the Memorial Sloan Kettering Cancer Center several patients have been treated successfully in the lateral decubitus position to overcome this set-up issue. In this report, the feasibility of the lateral decubitus set-up for patients who benefit from radiosurgery to the spine when and if they cannot tolerate standard supine position is explored.

OBJECTIVE

To report on a retrospective case series of three patients with a total of four lesions who were treated with radiosurgery for spinal metastases while set up in the lateral decubitus position.

METHODS AND MATERIALS

This is a retrospective case series of 3 patients who were treated with radiosurgery to the spine for palliation of painful metastatic foci. Patients were treated in the lateral decubitus position in 1-5 fractions in order to be eligible for this retrospective case series. Their set-up data, and clinical outcomes were then compared with historic controls.

RESULTS

Patients who were treated in the lateral decubitus position were set up reliably and reproducibly. Additionally clinical outcomes on routine follow-up and imaging, and toxicity profiles also corroborated the utility of this treatment set-up.

CONCLUSIONS

Routinely employing optical surface tracking during patient setup followed by KVCBCT prior to treatment delivery along with intra-fractional monitoring is safe and effective while utilizing the lateral decubitus position for the treatment of spinal metastases for patients who cannot tolerate the supine position. Finally the patient follow-up also corroborated that treatments were successful thus lending credence to the safety, ease, effectiveness, and feasibility of this patient set-up.

摘要

引言

在临床实践中,放射肿瘤学家经常会遇到需要对脊柱进行治疗的患者,这种情况常见于转移性疾病。这些转移瘤通常会导致疼痛、活动受限或神经功能缺损,因此需要加快治疗以减轻患者的痛苦。脊柱放射外科技术已广泛用于姑息治疗目的;然而,鉴于患者病情恶化、疼痛以及无法耐受麻醉,放射肿瘤学家常常面临一个难题:如果仰卧位不可行,如何为患者进行最佳的放射外科治疗准备。在纪念斯隆凯特琳癌症中心,已有数名患者在侧卧位成功接受了治疗,以解决这个摆位问题。在本报告中,探讨了对于受益于脊柱放射外科治疗但无法耐受标准仰卧位的患者,采用侧卧位摆位的可行性。

目的

报告一组回顾性病例系列,共3例患者,总计4个病灶,在侧卧位时接受了脊柱转移瘤的放射外科治疗。

方法和材料

这是一组回顾性病例系列,3例患者因疼痛性转移灶的姑息治疗接受了脊柱放射外科治疗。为符合本回顾性病例系列的条件,患者在侧卧位接受了1 - 5次分割治疗。然后将他们的摆位数据和临床结果与历史对照进行比较。

结果

在侧卧位接受治疗的患者摆位可靠且可重复。此外,常规随访和影像学检查的临床结果以及毒性特征也证实了这种治疗摆位的效用。

结论

对于无法耐受仰卧位的脊柱转移瘤患者,在患者摆位期间常规采用光学表面跟踪,然后在治疗前进行千伏锥形束计算机断层扫描(KVCBCT)以及分次内监测,是安全有效的。最后,患者随访也证实治疗是成功的,从而证明了这种患者摆位方式的安全性、简便性、有效性和可行性。

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