使用光声显微镜对微针介导的经皮纳米颗粒递送进行的研究。
studies of transdermal nanoparticle delivery with microneedles using photoacoustic microscopy.
作者信息
Moothanchery Mohesh, Seeni Razina Z, Xu Chenjie, Pramanik Manojit
机构信息
School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459, Singapore.
Both authors contributed equally.
出版信息
Biomed Opt Express. 2017 Nov 9;8(12):5483-5492. doi: 10.1364/BOE.8.005483. eCollection 2017 Dec 1.
Abstract
Microneedle technology allows micron-sized conduits to be formed within the outermost skin layers for both localized and systemic delivery of therapeutics including nanoparticles. Histological methods are often employed for characterization, and unfortunately do not allow for the visualization of the delivery process. This study presents the utilization of optical resolution-photoacoustic microscopy to characterize the transdermal delivery of nanoparticles using microneedles. Specifically, we observe the transdermal delivery of gold nanoparticles using microneedles in mice ear and study the penetration, diffusion, and spatial distribution of the nanoparticles in the tissue. The promising results reveal that photoacoustic microscopy can be used as a potential imaging modality for the characterization of microneedles based drug delivery.
摘要
微针技术可在最外层皮肤层内形成微米级管道，用于局部和全身递送包括纳米颗粒在内的治疗药物。组织学方法常用于表征，但遗憾的是无法实现递送过程的可视化。本研究利用光学分辨率光声显微镜对使用微针的纳米颗粒经皮递送进行表征。具体而言，我们观察了微针在小鼠耳部递送金纳米颗粒的过程，并研究了纳米颗粒在组织中的渗透、扩散和空间分布。这些有前景的结果表明，光声显微镜可作为一种潜在的成像方式，用于表征基于微针的药物递送。
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