Truong Van Gia, Park Suhyun, Tran Van Nam, Kang Hyun Wook
Interdisciplinary Program of Marine-Bio, Electrical & Mechanical Engineering, Pukyong National University, Busan, South Korea.
These authors contributed equally to this work.
Biomed Opt Express. 2017 Nov 16;8(12):5663-5674. doi: 10.1364/BOE.8.005663. eCollection 2017 Dec 1.
A uniformly diffusing applicator can be advantageous for laser treatment of tubular tissue. The current study investigated various conical angles for diffuser tips as a critical factor for achieving radially uniform light emission. A customized goniometer was employed to characterize the spatial uniformity of the light propagation. An model was developed to quantitatively compare the temperature development and irreversible tissue coagulation. The 10-mm diffuser tip with angle at 25° achieved a uniform longitudinal intensity profile (i.e., 0.90 ± 0.07) as well as a consistent thermal denaturation on the tissue. The proposed conical angle can be instrumental in determining the uniformity of light distribution for the photothermal treatment of tubular tissue.
均匀扩散式施照器对于管状组织的激光治疗可能具有优势。当前研究调查了扩散器尖端的各种圆锥角，将其作为实现径向均匀光发射的关键因素。采用定制的测角仪来表征光传播的空间均匀性。开发了一个模型以定量比较温度变化和不可逆的组织凝固情况。圆锥角为25°的10毫米扩散器尖端实现了均匀的纵向强度分布（即0.90±0.07）以及组织上一致的热变性。所提出的圆锥角有助于确定用于管状组织光热治疗的光分布均匀性。
