Shekarloo A, Mendez-Bauer C, Cook V, Freese U
Department of Obstetrics and Gynecology, Chicago Medical School, University of Health Sciences, IL.
Am J Obstet Gynecol. 1989 Mar;160(3):615-8. doi: 10.1016/s0002-9378(89)80041-9.
beta 2-Sympathomimetics have been used in acute intrapartum fetal distress to abolish uterine contractions and thus enable the fetal metabolism to recover before delivery. Because some serious complications were reported when a terbutaline intravenous bolus (0.25 mg) was used as a tocolytic, we assessed its safety and efficacy when used in patients not affected by cardiovascular disease, tachycardia greater than 100 beats/min, thyrotoxicosis, fluid overload, corticoids, atropine, or severe abruptio placentae. No maternal or fetal complications occurred in the 36 patients studied; a well-tolerated tachycardia developed in most patients. Fetal heart rate tracings and pH improved in 32 patients. Thirty-four neonates were delivered in good clinical and metabolic condition. We conclude that terbutaline intravenous bolus 0.25 mg is a safe and efficacious procedure when the proper indications and contraindications are followed.
β2-拟交感神经药已被用于治疗急性分娩期胎儿窘迫，以消除子宫收缩，从而使胎儿代谢在分娩前得以恢复。由于在将特布他林静脉推注（0.25毫克）用作宫缩抑制剂时报告了一些严重并发症，我们评估了其在未受心血管疾病、心率大于100次/分钟、甲状腺毒症、液体超负荷、皮质类固醇、阿托品或严重胎盘早剥影响的患者中使用时的安全性和有效性。在所研究的36例患者中未发生母体或胎儿并发症；大多数患者出现了耐受性良好的心动过速。32例患者的胎儿心率描记图和pH值有所改善。34例新生儿分娩时临床和代谢状况良好。我们得出结论，当遵循适当的适应证和禁忌证时，0.25毫克特布他林静脉推注是一种安全有效的方法。
