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大黄的生物活性成分、药理学及临床应用研究进展

Advances in bio-active constituents, pharmacology and clinical applications of rhubarb.

作者信息

Cao Yu-Jie, Pu Zong-Jin, Tang Yu-Ping, Shen Juan, Chen Yan-Yan, Kang An, Zhou Gui-Sheng, Duan Jin-Ao

机构信息

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023 Jiangsu China.

College of Pharmacy and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang, 712046 China.

出版信息

Chin Med. 2017 Dec 28;12:36. doi: 10.1186/s13020-017-0158-5. eCollection 2017.

DOI:10.1186/s13020-017-0158-5
PMID:29299052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5745730/
Abstract

Rhubarb is one of the most ancient, commonly used and important herbs in Chinese medicine. The modern researches of rhubarb clarified the efficacies, ingredients and mechanisms in a more scientific and rigorous way. The main chemical compositions of rhubarb include anthraquinones, anthrones, stilbenes, tannins, polysaccharides etc. These compositions show extensive pharmacological activities including regulating gastrointestinal, anticancer, antimicrobial, hepatoprotective, anti-inflammatory, protecting cardiovascular, cerebrovascular and so on. This paper reviews the recent studies on the active ingredients, pharmacological effects, clinical application and functional mechanism.

摘要

大黄是中药中最古老、常用且重要的草药之一。现代对大黄的研究以更科学、严谨的方式阐明了其功效、成分及作用机制。大黄的主要化学成分包括蒽醌类、蒽酮类、芪类、鞣质、多糖等。这些成分具有广泛的药理活性，包括调节胃肠道、抗癌、抗菌、保肝、抗炎、保护心血管、脑血管等。本文综述了大黄活性成分、药理作用、临床应用及作用机制的最新研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44d3/5745730/fefed998a9c4/13020_2017_158_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44d3/5745730/6e1751bef81d/13020_2017_158_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44d3/5745730/6edf9d12bd28/13020_2017_158_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44d3/5745730/f2d1da8688a0/13020_2017_158_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44d3/5745730/fefed998a9c4/13020_2017_158_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44d3/5745730/6e1751bef81d/13020_2017_158_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44d3/5745730/4d91b66c053e/13020_2017_158_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44d3/5745730/6edf9d12bd28/13020_2017_158_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44d3/5745730/f2d1da8688a0/13020_2017_158_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44d3/5745730/fefed998a9c4/13020_2017_158_Fig5_HTML.jpg

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Isolation and Identification of Secondary Metabolites in L.fil. Growing in Kazakhstan and Surveying of Its Anticancer Potential.哈萨克斯坦生长的丝状叶状地衣中次生代谢产物的分离与鉴定及其抗癌潜力研究
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