Karkhaneh Maryam, Qorbani Mostafa, Mohajeri-Tehrani Mohamad Reza, Hoseini Saeed
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
J Diabetes Metab Disord. 2017 Dec 28;16:49. doi: 10.1186/s40200-017-0330-6. eCollection 2017.
Increased serum complement C3 has been related to body fat mass, metabolic syndrome and chronic diseases. The purpose of this study was to evaluate the levels of C3 in the subjects of normal weight obese (hereafter NWO) as well as their possible relationships with metabolic syndrome and inflammation.
In this case-control study, 40 obese women with normal weight (body mass index (BMI) = 18.5-24.9 kg/m) and body fat percentage above 30% (fat mass (FM) > 30%) and 30 non-obese women (BMI = 18.5-24.9 kg/m2) and fat percentage less than 25% (FM < 25%) were selected as the study sample. Body composition was analyzed using Bio Impedance analyzer. Blood samples were then collected and analyzed for fasting serum concentration of lipid components of metabolic syndrome, insulin, serum complement C3 and High sensitivity C reactive protein (hsCRP).
Mean waist and hip circumferences in NWO was higher than non-NWO (74.78 ± 4.81 versus 70.76 ± 2.91 and 99.12 ± 4.32 versus 93.16 ± 2/91, respectively, -value < 0.001). However, the mean waist-to-hip ratio did not differ significantly ( = 0.448). The mean fasting serum concentration of complement C3, hsCRP and insulin was higher in NWO compared to that in non-NWO (-value < 0.05). Moreover, insulin sensitivity in NWO was lower than that in non-NWO (0.357 versus 0.374, -value = 0.043). Moreover, a significant correlation was found between body fat percentage and fasting serum complement C3 and insulin concentration ( = 0.417 and = 0.254, -value < 0.005, respectively).
Obese women with normal body mass index but high body fat percentage have higher serum C3 and are at a higher risk for metabolic dysregulation and metabolic syndrome than the healthy non-obese subjects.
血清补体C3升高与体脂量、代谢综合征及慢性疾病有关。本研究旨在评估正常体重肥胖者（以下简称NWO）的C3水平及其与代谢综合征和炎症的可能关系。
在这项病例对照研究中，选取40名体重正常（体重指数（BMI）=18.5 - 24.9kg/m²）且体脂百分比高于30%（脂肪量（FM）>30%）的肥胖女性以及30名非肥胖女性（BMI = 18.5 - 24.9kg/m²）且脂肪百分比低于25%（FM<25%）作为研究样本。使用生物电阻抗分析仪分析身体成分。随后采集血样，分析代谢综合征脂质成分、胰岛素、血清补体C3和高敏C反应蛋白（hsCRP）的空腹血清浓度。
NWO的平均腰围和臀围高于非NWO（分别为74.78±4.81对70.76±2.91以及99.12±4.32对93.16±2.91，P值<0.001）。然而，平均腰臀比无显著差异（P = 0.448）。NWO的补体C3、hsCRP和胰岛素的空腹血清平均浓度高于非NWO（P值<0.05）。此外，NWO的胰岛素敏感性低于非NWO（0.357对0.374，P值 = 0.043）。而且，体脂百分比与空腹血清补体C3和胰岛素浓度之间存在显著相关性（分别为r = 0.417和r = 0.254，P值<0.005）。
体重指数正常但体脂百分比高的肥胖女性血清C3水平较高，与健康非肥胖受试者相比，其代谢失调和代谢综合征风险更高。
