Fukushima Munehisa, Kitahara Tadashi, Oya Ryohei, Akahani Shiro, Inohara Hidenori, Naganawa Shinji, Takeda Noriaki
Department of Otolaryngology and Head and Neck Surgery Kansai Rosai Hospital Hyogo Japan.
Department of Otolaryngology and Head and Neck Surgery Osaka University, Graduate School of Medicine Osaka Japan.
Laryngoscope Investig Otolaryngol. 2017 Oct 31;2(6):344-350. doi: 10.1002/lio2.115. eCollection 2017 Dec.
OBJECTIVE/HYPOTHESIS: Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments.
Prospective, single-arm repeated measures.
Eleven MD patients were enrolled. All subjects prospectively underwent gadolinium-enhanced inner ear magnetic resonance (MR) imaging and neuro-otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months.
The frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13-91% of the pre-treatment level. The volume ratio of post-treatment EH-to-pre-treatment EH ranged from 1.01-3.22. The total volume of pre-treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level.
EH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period.
2b.
目的/假设：梅尼埃病（MD）是一种常见的内耳疾病，其特征为反复发作的眩晕、波动性感音神经性听力损失和耳鸣。其病理学定义为内耳内淋巴积水（EH），并且已推测EH与MD的临床症状相关。我们展示了MD患者在药物治疗期间体内EH的动态变化。
前瞻性、单臂重复测量。
纳入11例MD患者。所有受试者在药物治疗前后均前瞻性地接受了钆增强内耳磁共振（MR）成像和神经耳科学测试。通过处理MR图像对EH的体积进行定量评估。所有MD患者均接受持续药物治疗，并随访超过12个月。
所有患者的眩晕发作频率均降低，前庭功能降至治疗前水平的13% - 91%。治疗后EH与治疗前EH的体积比范围为1.01 - 3.22。治疗前EH的总体积与耳蜗症状病程及患耳听力水平显著相关。
MD患者的EH在药物治疗期间随着内耳功能的恶化而纵向发展。MD的自然病程可能至少在一定时期内随着EH的发展而进展。
2b。
