Carpenter R L, Eger E I
Department of Anesthesia, University of California, San Francisco.
Anesthesiology. 1989 Apr;70(4):630-5. doi: 10.1097/00000542-198904000-00014.
To determine the correlation between the partial pressures of anesthetics in venous and arterial blood (Pv and Pa), and to assess whether this correlation was better than that between the partial pressure of anesthetic in alveolar gas (PA) and Pa, isoflurane (n = 4) or halothane (n = 4) was administered to eight patients undergoing surgery, and Pv, PA, and Pa were measured. PA correlated with Pa better than did Pv (R = 0.960 vs. 0.878), and there was less variability in the data. Differences between Pv and Pa increased as the relative blood flow to the hand decreased [indicated by an increasing arterial-to-venous (a-v) O2 content difference]. The difference between PA and Pa was approximately 20% of the difference between inspired gas (PI) and Pa. The differences between PA and Pa appear to be due primarily to contamination of alveolar gas by physiologic dead space gas.
为了确定静脉血和动脉血中麻醉剂分压（Pv和Pa）之间的相关性，并评估这种相关性是否优于肺泡气中麻醉剂分压（PA）与Pa之间的相关性，对8例接受手术的患者给予异氟烷（n = 4）或氟烷（n = 4），并测量Pv、PA和Pa。PA与Pa的相关性优于Pv（R = 0.960对0.878），且数据变异性较小。随着手部相对血流量的减少[以动脉-静脉（a-v）氧含量差增加为指标]，Pv与Pa之间的差异增大。PA与Pa之间的差异约为吸入气（PI）与Pa之间差异的20%。PA与Pa之间的差异似乎主要是由于生理性无效腔气体对肺泡气的污染所致。
