Laboratory of Technical Biochemistry, Department of Biochemical and Chemical Engineering, TU Dortmund University, Dortmund, Germany.
Plant Biotechnology and Metabolic Engineering, Technische Universität Darmstadt, Darmstadt, Germany.
Planta Med. 2018 Mar;84(4):214-220. doi: 10.1055/s-0043-125087. Epub 2018 Jan 4.
The plant contains a number of psychoactive chemical compounds, the cannabinoids, which possess a significant pharmaceutical potential. Recently, the usage of for medicinal purposes was legalized in many countries. Thus, the study on the influence of different cannabinoids in combination with other -derived compounds with respect to the treatment of various diseases becomes increasingly important. Besides the production of distinct cannabinoids in a heterologous host, like tobacco or yeast, transgenic plants would be a suitable alternative to modify and therefore optimize the cannabinoid profile. This perspective highlights the current efforts on cell culture systems, propagation, and transformation of the plant and reveals the resulting opportunities concerning biotechnological production of cannabinoids. Furthermore, alternative platform organisms for the heterologous production of cannabinoids, like tobacco, are considered and evaluated.
该植物含有多种具有显著药用潜力的精神活性化学化合物，即大麻素。最近，许多国家已经将大麻用于医疗目的合法化。因此，研究不同大麻素与其他衍生化合物的组合对各种疾病的治疗作用变得越来越重要。除了在烟草或酵母等异源宿主中生产不同的大麻素外，转基因大麻植物也是一种合适的替代方法，可以对其进行修饰和优化大麻素的特征。这一观点强调了当前在大麻细胞培养系统、繁殖和转化方面的努力，并揭示了在大麻素生物制造方面的相关机会。此外，还考虑和评估了烟草等用于大麻素异源生产的替代平台生物。
