Kim Jin Taek, Lee Hong Kyu
Department of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea.
Ann Pediatr Endocrinol Metab. 2017 Dec;22(4):219-225. doi: 10.6065/apem.2017.22.4.219. Epub 2017 Dec 31.
The prevalence of obesity around the world has increased sharply. Strong evidence has emerged over the last decades that human exposure to numerous endocrine disrupting chemicals (EDCs) is the cause of obesity and obesity-related metabolic diseases. Many EDCs are manmade chemicals that are released into the environment. EDCs are exogenous compounds that interfere with hormonal regulation and normal endocrine systems, thereby affecting the health of animals and humans. The number of chemicals belonging to EDCs is increasing and some of them are very stable; they persist in the environment (persistent organic pollutants). Although they are banned, their concentrations have been continuously increasing over time. This review gives a brief introduction to common EDCs, and evidence of harmful effects of EDCs on obesity-related diseases; we focus in particular on EDCs' role in causing mitochondrial dysfunction.
全球肥胖率急剧上升。在过去几十年中，有强有力的证据表明，人类接触大量内分泌干扰化学物质（EDC）是导致肥胖及肥胖相关代谢疾病的原因。许多EDC是释放到环境中的人造化学物质。EDC是干扰激素调节和正常内分泌系统的外源性化合物，从而影响动物和人类的健康。属于EDC的化学物质数量在增加，其中一些非常稳定；它们在环境中持续存在（持久性有机污染物）。尽管它们已被禁止，但随着时间的推移，其浓度一直在不断增加。本综述简要介绍了常见的EDC，以及EDC对肥胖相关疾病有害影响的证据；我们特别关注EDC在导致线粒体功能障碍中的作用。
