Edge Ruth, Truscott T George
Dalton Cumbrian Facility, The University of Manchester, Westlakes Science and Technology Park, Moor Row, Cumbria CA24 3HA, UK.
School of Chemical and Physical Sciences, Lennard-Jones Building, Keele University, Staffordshire ST5 5BG, UK.
Antioxidants (Basel). 2018 Jan 1;7(1):5. doi: 10.3390/antiox7010005.
We report on studies of reactions of singlet oxygen with carotenoids and retinoids and a range of free radical studies on carotenoids and retinoids with emphasis on recent work, dietary carotenoids and the role of oxygen in biological processes. Many previous reviews are cited and updated together with new data not previously reviewed. The review does not deal with computational studies but the emphasis is on laboratory-based results. We contrast the ease of study of both singlet oxygen and polyene radical cations compared to neutral radicals. Of particular interest is the switch from anti- to pro-oxidant behavior of a carotenoid with change of oxygen concentration: results for lycopene in a cellular model system show total protection of the human cells studied at zero oxygen concentration, but zero protection at 100% oxygen concentration.
我们报告了关于单线态氧与类胡萝卜素和视黄醇反应的研究，以及一系列关于类胡萝卜素和视黄醇的自由基研究，重点是近期的工作、膳食类胡萝卜素以及氧在生物过程中的作用。引用并更新了许多以前的综述以及以前未综述的新数据。本综述不涉及计算研究，重点是基于实验室的结果。我们对比了与中性自由基相比，单线态氧和多烯自由基阳离子研究的难易程度。特别令人感兴趣的是，随着氧浓度的变化，类胡萝卜素从抗氧化剂行为转变为促氧化剂行为：细胞模型系统中番茄红素的结果表明，在零氧浓度下，所研究的人类细胞得到了完全保护，但在100%氧浓度下则没有保护作用。
