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[在布鲁氏菌病(羊种布鲁氏菌)疫区,母羊接种H.38或Rev.1疫苗后血清学和过敏反应的持续性]

[Persistence of serologic and allergic reactions in ewes after vaccination with the H.38 or Rev.1 vaccines in a brucellosis (Brucella melitensis) enzootic area].

作者信息

Pardon P, Sanchis R, Molenat G, Bouchard N, Schmitt D, Marly J, Durand M

机构信息

INRA, Station de pathologie de la reproduction, Unité de pathologie infectieuse ovine, Monnaie, France.

出版信息

Ann Rech Vet. 1989;20(1):65-72.

PMID:2930135
Abstract

In a flock of 2,000 ewes located in an endemic area of Brucella melitensis infection, subjected to systematic vaccination of lambs either with killed and adjuvanted B. melitensis H.38 vaccine from 1973 to 1978, or with living B. melitensis Rev.1 vaccine since 1979, reactions to allergic intrapalpebral test, complement fixation test and Rose Bengal plate test were recorded in small groups of animals vaccinated four, three, two or one years ago. Four years after H.38 vaccination, 39 ewes out of 40 (97%) remained positive at least to one of the three tests. After vaccination with strain Rev.1, 16% out of 153 ewes vaccinated one to four years before were positive. These results were discussed according to two aspects: 1) infectious or vaccinal origins of these positive reactions; 2) consequences on implement of test and slaughter procedures in a vaccinated flock: allergic or complement fixation tests would have led to eliminate 9% out of ewes vaccinated with the Rev.1 vaccine, but only 1% with the Rose Bengal plate test.

摘要

在一群位于布鲁氏菌感染流行地区的2000只母羊中,1973年至1978年对羔羊系统性接种了灭活并添加佐剂的马尔他布鲁氏菌H.38疫苗,自1979年起接种马尔他布鲁氏菌Rev.1活疫苗。对4年前、3年前、2年前或1年前接种疫苗的小群动物记录了其对过敏睑内试验、补体结合试验和玫瑰红平板试验的反应。接种H.38疫苗4年后,40只母羊中有39只(97%)至少对三项试验中的一项仍呈阳性。接种Rev.1菌株疫苗后,1至4年前接种疫苗的153只母羊中有16%呈阳性。从两个方面对这些结果进行了讨论:1)这些阳性反应的感染性或疫苗性来源;2)对接种疫苗的羊群实施检测和屠宰程序的影响:过敏试验或补体结合试验会导致接种Rev.1疫苗的母羊中有9%被淘汰,但玫瑰红平板试验仅导致1%被淘汰。

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Ann Rech Vet. 1989;20(1):65-72.
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