[母羊针对实验性羊布鲁氏菌感染的免疫接种：十一种疫苗的比较]

[Immunization of ewes against experimental Brucella melitensis infection: comparison of eleven vaccines].

作者信息

Gaumont R, Trap D, Gayot G, Pierre F, Dhennin L

出版信息

Dev Biol Stand. 1976;31:377-86.

Abstract

A comparative study of 11 antibrucellic vaccines has been carried out in the Limousin region of 360 ewe-lambs divided into groups of 30, a 12th group serving as control. After being vaccinated at 8 months, the ewe-lambs were covered between 9 1/2 and 10 1/2 months, then infected at 11 months with Br. melitensis strain 53 H 38 by instillation of 4 x 10(6) germs on the conjonctiva. Six of these vaccines reduced the number of abortions and the excretion of brucella at parturition: three consisted of an inactivated suspension of a virulent S strain of Br. melitensis in oily adjuvant, another consisted of an inactivated suspension of a modified non-agglutinogenic strain of Br. melitensis also in oily adjuvant, the fifth was prepared from Br. melitensis H 105 and Br. abortus B 112 with saponin and the sixth from a strain of Br. melitensis modified with aluminium hydroxide as adjuvant.

摘要

在利木赞地区对11种抗布鲁氏菌疫苗进行了比较研究，将360只母羊羔分成每组30只的组，第12组作为对照。8个月大时进行疫苗接种，母羊羔在9个半月至10个半月期间受孕，然后在11个月时通过在结膜上滴注4×10⁶个细菌感染53 H 38布鲁氏菌 melitensis菌株。其中六种疫苗减少了流产数量和分娩时布鲁氏菌的排泄：三种由布鲁氏菌 melitensis强毒株S的灭活悬液加油性佐剂组成，另一种由布鲁氏菌 melitensis改良的非凝集原性菌株的灭活悬液加油性佐剂组成，第五种由布鲁氏菌 melitensis H 105和布鲁氏菌 abortus B 112加皂苷制成，第六种由用氢氧化铝作为佐剂改良的布鲁氏菌 melitensis菌株制成。

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