Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Trends Parasitol. 2018 Apr;34(4):310-321. doi: 10.1016/j.pt.2017.12.004. Epub 2018 Jan 2.
Arboviruses such as West Nile, Zika, chikungunya, dengue, and yellow fever viruses have become highly significant global pathogens through unexpected, explosive outbreaks. While the rapid progression and frequency of recent arbovirus outbreaks is associated with long-term changes in human behavior (globalization, urbanization, climate change), there are direct mosquito-virus interactions which drive shifts in host range and alter virus transmission. This review summarizes how virus-mosquito interactions are critical for these viruses to become global pathogens at molecular, physiological, evolutionary, and epidemiological scales. Integrated proactive approaches are required in order to effectively manage the emergence of mosquito-borne arboviruses, which appears likely to continue into the indefinite future.
虫媒病毒（如西尼罗河病毒、寨卡病毒、基孔肯雅热病毒、登革热病毒和黄热病病毒）通过意外的、爆发性的暴发，已成为具有高度重要性的全球病原体。虽然最近虫媒病毒暴发的快速进展和频率与人类行为的长期变化（全球化、城市化、气候变化）有关，但直接的蚊虫-病毒相互作用推动了宿主范围的转变，并改变了病毒的传播。本综述总结了病毒-蚊虫相互作用在这些病毒成为全球病原体方面的重要性，从分子、生理、进化和流行病学的角度来看都是如此。为了有效管理蚊媒传播的虫媒病毒的出现，需要采取综合的主动方法，而这种情况在可预见的未来似乎还会继续。
