Silverman J A, Corbett D
University of Pittsburgh School of Medicine, PA.
Behav Brain Res. 1989 Feb 1;32(1):43-50. doi: 10.1016/s0166-4328(89)80070-1.
A curve-shift paradigm was used to assess the effects of lesions of the prefrontal cortex on self-stimulation from electrode sites in the substantia nigra. Combined lesions of the medial and sulcal cortical regions severely attenuated substantia nigra self-stimulation. These results are discussed in the context of the frontal cortex and the substantia nigra as belonging to a reinforcement system that is largely independent of the medial forebrain bundle system.
