Song Sang-Hyun, Kim Tae-You
Cancer Genomics Research Laboratory, Cancer Research Institute, Seoul National University, Seoul 03080, Korea.
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Korea.
Genomics Inform. 2017 Dec;15(4):114-122. doi: 10.5808/GI.2017.15.4.114. Epub 2017 Dec 29.
It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex. Their dynamic interactions in three dimensions within the nucleus regulate gene transcription by changing the chromatin architecture. Such spatial genomic organization is functionally important for the spatial disposition of chromosomes to control cell fate during development and differentiation. Thus, the dysregulation of proper long-range chromatin interactions may influence the development of tumorigenesis and cancer progression.
越来越明显的是，真核生物基因组受到CCCTC结合因子/黏连蛋白复合体介导的高阶染色质组织的影响。它们在细胞核内三维空间中的动态相互作用通过改变染色质结构来调节基因转录。这种空间基因组组织对于染色体在发育和分化过程中控制细胞命运的空间布局在功能上具有重要意义。因此，适当的长程染色质相互作用失调可能会影响肿瘤发生和癌症进展。
