Ibrahim Sabrin Ragab Mohamed, Mohamed Gamal Abdallah, Elfaky Mahmoud Abdelkhalek, Al Haidari Rwaida Adel, Zayed Mohamed Fathalla, El-Kholy Amal Abd-Elmoneim, Khedr Amgad Ibrahim Mansour
a Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy , Taibah University , Al Madinah Al Munawwarah 30078 , Saudi Arabia.
b Department of Pharmacognosy, Faculty of Pharmacy , Assiut University , Assiut 71526 , Egypt.
J Asian Nat Prod Res. 2019 Mar;21(3):291-297. doi: 10.1080/10286020.2017.1423058. Epub 2018 Jan 7.
A new prenylated xanthone, garcixanthone A (5), together with eight known compounds, mangostanaxanthones I (1) and II (2), garcinone E (3), β-mangostin (4), 8-hydroxycudraxanthone G (6), garcinone C (7), cudraxanthone G (8), and (-)-epicatechin (9) were isolated from the EtOAc-soluble fraction of the air-dried pericarps of Garcinia mangostana (family Clusiaceae). Their structures were verified on the basis of spectroscopic data interpretation as well as comparison with the literature. The cytotoxic and antimicrobial activities of the new compound were assessed using sulforhodamine B (SRB) and agar disk diffusion assays, respectively. Compound 5 showed significant cytotoxic potential against epithelial lung carcinoma (A549) and breast carcinoma (MCF7) cell lines with ICs 3.0 and 4.2 μM, respectively, compared to doxorubicin (0.74 and 0.41 μM, respectively).
从山竹（藤黄科）风干果皮的乙酸乙酯可溶部分中分离出一种新的异戊烯基呫吨酮，即藤黄异戊烯基呫吨酮A（5），以及8种已知化合物，分别为山竹呫吨酮I（1）、山竹呫吨酮II（2）、藤黄宁E（3）、β-倒捻子素（4）、8-羟基苦木呫吨酮G（6）、藤黄宁C（7）、苦木呫吨酮G（8）和（-）-表儿茶素（9）。通过光谱数据解析以及与文献对比对它们的结构进行了确证。分别采用磺酰罗丹明B（SRB）法和琼脂平板扩散法对新化合物的细胞毒性和抗菌活性进行了评估。与阿霉素（分别为0.74和0.41μM）相比，化合物5对上皮性肺癌（A549）和乳腺癌（MCF7）细胞系显示出显著的细胞毒性潜力，IC50分别为3.0和4.2μM。
