Andrology and IVF Laboratories, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah.
Andrology and IVF Laboratories, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah.
Fertil Steril. 2018 Jan;109(1):27-32. doi: 10.1016/j.fertnstert.2017.11.006.
Although direct correlates between cancer and infertile epigenetic profiles are rare, the general similarities between the two disease processes offer insights into the study of both abnormalities. Foremost among them is the nature of these pathologies, where one disease (cancer) is categorized by an inability to control or inhibit cellular proliferation, and the other (male infertility) is caused by an inability to maintain the normally efficient extreme proliferation of the male germ cell. Based on this similarity alone, the study of epigenetics in both male fertility and cancer has the potential to offer intriguing insights in both fields. The creative application of harmonious studies of both infertility and cancer is likely to yield useful and informative data that may aid in both the understanding and treatment of both pathologies.
虽然癌症和不孕的表观遗传特征之间很少有直接的关联，但这两种疾病过程的一般相似之处为这两种异常的研究提供了一些启示。其中最重要的是这些病变的性质，一种疾病（癌症）的特征是无法控制或抑制细胞增殖，而另一种疾病（男性不育）则是由于无法维持男性生殖细胞的正常高效极度增殖所致。仅基于这种相似性，对男性生育力和癌症中的表观遗传学的研究有可能为这两个领域提供有趣的见解。创造性地应用不孕和癌症的和谐研究很可能产生有用和有信息的的数据，这可能有助于理解和治疗这两种病理。
