Malmgren R, Aberg-Wistedt A, Mårtensson B
Department of Experimental Surgery, Karolinska Institute, Stockholm, Sweden.
Biol Psychiatry. 1989 Feb 15;25(4):393-402. doi: 10.1016/0006-3223(89)90192-3.
The serotonin uptake in platelets of 120 healthy volunteers and 64 endogenously depressed patients was investigated over a 2-year period. In healthy individuals, Km exhibited a significant seasonal rhythm during the bright half of the year. The seasonal rhythm of Vmax assumes the form of a sine curve, with nadir values at the vernal and autumn equinoxes and peak values at the winter and summer solstices. Km in patients was higher than in controls in February and October, and the seasonal variation of Km differed between patients and controls. The monthly mean values of Vmax in patients were, as a rule, lower than corresponding values in controls, but significantly so only in December. Patients had higher Vmax than controls in October and November, and the seasonal variation of Vmax in patients differed from that of controls. The results suggest that Km, a measure of the affinity of the serotonin uptake site, may be subject to photoperiodic regulation in healthy individuals. The annual variation in uptake site densities, as judged by the changes in Vmax, are probably generated by an endogenous superior oscillator. The aberrant uptake kinetics found in the endogenously depressed patients may reflect seasonal susceptibility to the disorder and/or altered serotonergic rhythmicity.
在两年的时间里，对120名健康志愿者和64名内源性抑郁症患者血小板中的血清素摄取情况进行了研究。在健康个体中，Km在一年中较明亮的半年期间呈现出显著的季节性节律。Vmax的季节性节律呈正弦曲线形式，在春分和秋分时出现最低点，在冬至和夏至时出现峰值。患者的Km在2月和10月高于对照组，且患者和对照组之间Km的季节性变化有所不同。患者Vmax的月平均值通常低于对照组的相应值，但仅在12月时差异显著。患者在10月和11月的Vmax高于对照组，且患者Vmax的季节性变化与对照组不同。结果表明，Km作为血清素摄取位点亲和力的一种度量，在健康个体中可能受光周期调节。根据Vmax的变化判断，摄取位点密度的年度变化可能由内源性高级振荡器产生。在内源性抑郁症患者中发现的异常摄取动力学可能反映了该疾病的季节性易感性和/或血清素能节律的改变。
