Zhang Xihai, Chen Ge, Wang Jun, Tang Lian, Yin Yiran
Dept. of Orthopedics, Affiliated Hospital of Southwest Medical University, Luzhou, PR China.
Iran J Public Health. 2017 Oct;46(10):1318-1323.
This paper is aimed at studying the therapeutic effects of replantation of alcohol-devitalized bone segments to treat malignant bone tumors of the knee joint.
We retrospectively analyzed clinical data for 45 patients from January 2013 to January 2016 who underwent replantation following alcohol-devitalization of bone segments and 40 who underwent prosthesis implantation. The two groups were comparable in basal clinical biometric data, including gender, age, tumor type and location, Enneking staging, and maximum tumor diameter. Radical tumor resection was combined with neoadjuvant chemotherapy following the two-implantation procedures.
The median follow-up time was 25 months, and the outcomes were compared. We found no differences in the length of bone lesions, surgery time, intraoperative blood loss, amount of postoperative drainage, and perioperative complications, which were just three for each method. We also found no significant differences in limb function scores, internal fixation imaging scores, tumor-free survival rate, and overall survival rate between the two groups. Replantation following alcohol-devitalization of tumor-bearing bone segment demonstrated similar clinical outcomes compared with prosthesis implantation in the treatment of primary malignant bone tumors of the knee joint.
Both therapies enjoy good application safety and effectiveness. Because alcohol devitalization is inexpensive and easy to apply in the clinic, it should be considered a preferred method in the treatment of bone tumors.
本文旨在研究酒精灭活骨段再植治疗膝关节恶性骨肿瘤的疗效。
我们回顾性分析了2013年1月至2016年1月期间45例行酒精灭活骨段再植患者和40例行假体植入患者的临床资料。两组患者的基础临床生物特征数据具有可比性，包括性别、年龄、肿瘤类型和位置、Enneking分期以及肿瘤最大直径。两种植入手术后均采用根治性肿瘤切除联合新辅助化疗。
中位随访时间为25个月，并对结果进行了比较。我们发现骨病变长度、手术时间、术中出血量、术后引流量及围手术期并发症方面无差异，每种方法各有3例。两组在肢体功能评分、内固定影像学评分、无瘤生存率和总生存率方面也无显著差异。在治疗膝关节原发性恶性骨肿瘤方面，酒精灭活瘤骨段再植与假体植入相比显示出相似的临床结果。
两种治疗方法均具有良好的应用安全性和有效性。由于酒精灭活成本低廉且易于在临床应用，应将其视为骨肿瘤治疗的首选方法。
