杏鲍菇 SI-04 胞外多糖的抗氧化、降血糖和肾保护作用。
Antioxidation, anti-hyperglycaemia and renoprotective effects of extracellular polysaccharides from Pleurotus eryngii SI-04.
机构信息
College of Life Science, Shandong Agricultural University, Tai'an 271018, China.
The Central Hospital of Tai'an, Tai'an 271000, China.
出版信息
Int J Biol Macromol. 2018 May;111:219-228. doi: 10.1016/j.ijbiomac.2018.01.009. Epub 2018 Jan 6.
The present study was designed to investigate the anti-hyperglycaemia, hypolipidemia and renoprotective effects of two extracellular polysaccharides (EPS) from the broth of Pleurotus eryngii SI-04 (EPS1 and EPS2) in mice with streptozotocin (STZ)-induced diabetic nephropathy (DN). The results showed that both EPS1 and EPS2 exhibited potential anti-DN effects, including significantly decreasing GLU levels; suppressing ALB, BUN, CRE and UA levels; reducing serum lipid (TC, TG, VLDL-C and LDL-C) levels; improving renal antioxidant status (GSH-Px, SOD, CAT and MDA); and attenuating pathological nephropathy damage. These results demonstrated that both EPS1 and EPS2 exhibited potential antioxidant, anti-hyperglycaemic, and renoprotective effects against STZ-induced DN, indicating that P. eryngii SI-04 could be used as a functional food and natural drug. In addition, the monosaccharide compositions and bond types of these two polysaccharides were analysed.
本研究旨在探讨杏鲍菇 SI-04 发酵液中两种胞外多糖（EPS1 和 EPS2）对链脲佐菌素（STZ）诱导的糖尿病肾病（DN）小鼠的降血糖、降血脂和肾保护作用。结果表明，EPS1 和 EPS2 均具有潜在的抗 DN 作用，包括显著降低 GLU 水平；抑制 ALB、BUN、CRE 和 UA 水平；降低血清脂质（TC、TG、VLDL-C 和 LDL-C）水平；改善肾脏抗氧化状态（GSH-Px、SOD、CAT 和 MDA）；减轻病理肾病损伤。这些结果表明，EPS1 和 EPS2 均具有潜在的抗氧化、降血糖和肾保护作用，可用于防治 STZ 诱导的 DN，表明杏鲍菇 SI-04 可作为功能性食品和天然药物使用。此外，还分析了这两种多糖的单糖组成和键型。
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