Bartrons R, Carreras M, Climent F, Carreras J
Biochim Biophys Acta. 1985 Sep 27;842(1):52-5. doi: 10.1016/0304-4165(85)90292-2.
Fructose 2,6-bisphosphate inhibits phosphoglucomutase. The inhibition is mixed with respect to glucose 1,6-bisphosphate and non-competitive with respect to glucose 1-phosphate. In contrast with fructose 1,6-bisphosphate and glycerate 1,3-bisphosphate, which also possess inhibitory effect, fructose 2,6-bisphosphate does not phosphorylate phosphoglucomutase. Fructose 2,6-bisphosphate preparations contain contaminants which can explain artefactual results previously reported.
果糖2,6 -二磷酸抑制磷酸葡萄糖变位酶。这种抑制作用对于1,6 -二磷酸葡萄糖而言是混合型的，而对于1 -磷酸葡萄糖而言是非竞争性的。与同样具有抑制作用的1,6 -二磷酸果糖和1,3 -二磷酸甘油酸不同，果糖2,6 -二磷酸不会使磷酸葡萄糖变位酶磷酸化。果糖2,6 -二磷酸制剂含有一些污染物，这可以解释先前报道的人为结果。
