UPMC Hillman Cancer Center, Pittsburgh, PA 15213.
UPMC Hillman Cancer Center, Pittsburgh, PA 15213;
J Immunol. 2018 Jan 15;200(2):443-449. doi: 10.4049/jimmunol.1701024.
Dendritic cells (DC) are specialized immune cells that play a critical role in promoting an immune response against Ags, which can include foreign pathogenic Ags and self-tumor Ags. DC are capable of boosting a memory T cell response but most importantly they are effective initiators of naive T cell responses. Many years of studies have focused on the use of DC vaccines against cancer to initiate and shape an antitumor-specific immune response and/or boost existing spontaneous antitumor T cell responses. In this study we give a brief overview of DC biology, function, and cellular subsets, and review the current status of the field of DC as cancer vaccines.
树突状细胞（DC）是一种专门的免疫细胞，在促进针对抗原的免疫反应中起着关键作用，这些抗原包括外来的病原性抗原和自身肿瘤抗原。DC 能够增强记忆 T 细胞反应，但最重要的是，它们是有效启动幼稚 T 细胞反应的细胞。多年的研究集中在使用 DC 疫苗来对抗癌症，以启动和塑造针对肿瘤的特异性免疫反应和/或增强现有的自发抗肿瘤 T 细胞反应。在本研究中，我们简要概述了 DC 的生物学、功能和细胞亚群，并回顾了 DC 作为癌症疫苗领域的现状。
