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从海洋来源真菌曲霉属SF-5280中分离并鉴定一种新型二酮哌嗪二聚体的结构

Isolation and structure determination of a new diketopiperazine dimer from marine-derived fungus Aspergillus sp. SF-5280.

作者信息

Cho Kwang-Ho, Sohn Jae Hak, Oh Hyuncheol

机构信息

a College of Pharmacy , Wonkwang University , Iksan , Republic of Korea.

b College of Medical and Life Sciences , Silla University , Busan , Republic of Korea.

出版信息

Nat Prod Res. 2018 Jan;32(2):214-221. doi: 10.1080/14786419.2017.1346642. Epub 2017 Jul 3.

DOI:10.1080/14786419.2017.1346642
PMID:28670919
Abstract

A new diketopiperazine dimer designated as SF5280-415 (1) was isolated from an EtOAc extract of the marine-derived fungus Aspergillus sp. SF-5280 by various chromatographic methods. The structure of 1 was mainly determined by analysis of the NMR spectroscopic data and MS data, along with Marfey's method. This compound is a new diastereoisomer of known bispyrrolidinoindoline diketopiperazine alkaloid WIN 64745, which possesses unique architecture biosynthetically derived from an indole oxidation reaction of tryptophan.

摘要

通过各种色谱方法，从海洋来源的真菌曲霉属SF-5280的乙酸乙酯提取物中分离出一种新的二酮哌嗪二聚体，命名为SF5280-415（1）。1的结构主要通过核磁共振光谱数据和质谱数据的分析以及马尔费方法确定。该化合物是已知的双吡咯烷基吲哚啉二酮哌嗪生物碱WIN 64745的一种新的非对映异构体，其具有通过色氨酸吲哚氧化反应生物合成衍生的独特结构。

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