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源自海绵共生真菌sp. SCSIO F46的苯酚衍生物

Phenol Derivatives From the Sponge-Derived Fungus sp. SCSIO F46.

作者信息

Tian Yongqi, Lin Xiuping, Zhou Xuefeng, Liu Yonghong

机构信息

College of Biological Science and Technology, Fuzhou University, Fuzhou, China.

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.

出版信息

Front Chem. 2018 Nov 1;6:536. doi: 10.3389/fchem.2018.00536. eCollection 2018.

DOI:10.3389/fchem.2018.00536
PMID:30443544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6221957/
Abstract

Seven new phenol derivatives named coleophomones E and F (, ), diorcinols L and M (, ), 1-hydroxy-6-methyl-11-methoxy-8-hydroxymethylxanthone (), porric acid E (), and 7-(2-hydroxyphenyl) butane-7,8,9-triol (), were isolated from the EtOAc extract of the marine sponge-derived fungus sp. SCSIO F46, together with 10 known compounds. Their structures were determined by spectroscopic analyses, including NMR, MS, X-ray diffraction, and theoretical calculations. Each of and contains an unusual spiro [cyclohexane-1,2'-inden] moiety, which is relatively seldom in nature products. Cytotoxic and COX-2 inhibitory activities of all purified compounds were tested and evaluated. Compound displayed obvious cytotoxicities against Huh-7, HeLa, DU145 and HL60 cells (IC values 5.7-9.6 μM) and weak activities against other five cell lines, while showed weak cytotoxicities against HeLa and HL7702 cells. Compound displayed COX-2 inhibitory activity with IC value of 3.3 μM.

摘要

从海洋海绵来源的真菌SCSIO F46的乙酸乙酯提取物中分离出七种新的酚类衍生物，分别命名为鞘脂菌素E和F（，）、二间苯二酚L和M（，）、1-羟基-6-甲基-11-甲氧基-8-羟甲基呫吨酮（）、多孔酸E（）和7-（2-羟基苯基）丁烷-7,8,9-三醇（），同时还分离出10种已知化合物。通过包括核磁共振（NMR）、质谱（MS）、X射线衍射和理论计算在内的光谱分析确定了它们的结构。和中的每一个都含有一个不寻常的螺[环己烷-1,2'-茚]部分，这在天然产物中相对较少见。对所有纯化化合物的细胞毒性和COX-2抑制活性进行了测试和评估。化合物对Huh-7、HeLa、DU1（此处原文有误，推测为DU145）和HL60细胞表现出明显的细胞毒性（IC值为5.7 - 9.6 μM），对其他五种细胞系表现出较弱的活性，而对HeLa和HL7702细胞表现出较弱的细胞毒性。化合物表现出COX-2抑制活性，IC值为3.3 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/025f/6221957/eddb335e9012/fchem-06-00536-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/025f/6221957/2f7445af0684/fchem-06-00536-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/025f/6221957/d35db4b5e45e/fchem-06-00536-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/025f/6221957/1dcd75ecdfcb/fchem-06-00536-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/025f/6221957/3e810a4a5ef6/fchem-06-00536-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/025f/6221957/eddb335e9012/fchem-06-00536-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/025f/6221957/2f7445af0684/fchem-06-00536-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/025f/6221957/d35db4b5e45e/fchem-06-00536-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/025f/6221957/1dcd75ecdfcb/fchem-06-00536-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/025f/6221957/3e810a4a5ef6/fchem-06-00536-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/025f/6221957/eddb335e9012/fchem-06-00536-g0005.jpg

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