Centre for Additive Manufacturing, School of Engineering, RMIT University, Melbourne, Victoria 3000, Australia.
Biomater Sci. 2018 Jan 30;6(2):250-264. doi: 10.1039/c7bm01016h.
Implant surfaces play important roles in regulating protein adsorption and determining subsequent cell responses, including cell attachment, proliferation, migration and differentiation. With rapid developments in micro- and nano-fabrication methods and additive manufacturing (3D printing) technologies, precisely controlled patterns such as partially ordered or ordered patterns can now be generated on bone implant surfaces, rather than restricted to randomly roughened surfaces. Over the last two decades, much effort has been dedicated to manipulating cell responses through surface topographical modifications. This review discusses the recent developments and understanding of surface topography in prompting or enhancing desired cell responses, particularly the roles of ordered and partially ordered surface topography under in vitro conditions. In addition, the challenges to translate research findings into implant applications are addressed.
植入物表面在调节蛋白质吸附和决定随后的细胞反应方面起着重要作用，包括细胞附着、增殖、迁移和分化。随着微纳加工方法和增材制造（3D 打印）技术的快速发展，现在可以在骨植入物表面上生成精确控制的图案，如部分有序或有序图案，而不仅仅局限于随机粗糙表面。在过去的二十年中，人们致力于通过表面形貌修饰来操纵细胞反应。本文综述了表面形貌在促进或增强所需细胞反应方面的最新进展和认识，特别是有序和部分有序表面形貌在体外条件下的作用。此外，还讨论了将研究结果转化为植入物应用的挑战。
