Liu Aiguo, Wang Chenxu, Deng Shuang, Zhang Sitong, Zhao Ziwen, Xiao Han, Ying Ting, Yi Chengqing, Li Dejian
Department of Orthopedics, The First Affiliated Hospital of Henan University, Kaifeng 475000, China.
Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai 201300, China.
Pharmaceutics. 2025 Jan 13;17(1):98. doi: 10.3390/pharmaceutics17010098.
The application of light-responsive nanomaterials (LRNs) in bone tissue engineering shows broad prospects, especially in promoting bone healing and regeneration. With a deeper understanding of the mechanisms of bone defects and healing disorders, LRNs are receiving increasing attention due to their non-invasive, controllable, and efficient properties. These materials can regulate cellular biological reactions and promote bone cell adhesion, proliferation, and differentiation by absorbing specific wavelengths of light and converting them into physical and chemical signals. In addition, the unique surface morphology and biocompatibility of LRNs enable them to effectively load drugs in bone tissue engineering, achieve precise release, and optimize the bone regeneration process. Through photothermal and photodynamic therapy, these materials also possess antibacterial properties and can play an important role in the repair of infectious bone defects. Although LRNs have shown significant advantages in bone tissue regeneration, a series of challenges still need to be overcome to achieve their widespread and effective clinical applications. This article summarizes the basic principles, classification, and potential applications of LRNs in bone tissue regeneration, aiming to provide reference for future research and clinical applications.
光响应性纳米材料（LRNs）在骨组织工程中的应用展现出广阔前景，尤其是在促进骨愈合和再生方面。随着对骨缺损及愈合障碍机制的深入理解，LRNs因其非侵入性、可控性和高效性而受到越来越多的关注。这些材料可通过吸收特定波长的光并将其转化为物理和化学信号，来调节细胞生物学反应并促进骨细胞的黏附、增殖和分化。此外，LRNs独特的表面形态和生物相容性使其能够在骨组织工程中有效地负载药物，实现精准释放，并优化骨再生过程。通过光热和光动力疗法，这些材料还具有抗菌性能，可在感染性骨缺损的修复中发挥重要作用。尽管LRNs在骨组织再生方面已显示出显著优势，但要实现其广泛有效的临床应用仍需克服一系列挑战。本文总结了LRNs在骨组织再生中的基本原理、分类及潜在应用，旨在为未来的研究和临床应用提供参考。
