Zhao Zeqing, Liu Jin, Weir Michael D, Schneider Abraham, Ma Tao, Oates Thomas W, Xu Hockin H K, Zhang Ke, Bai Yuxing
Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China.
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
Front Bioeng Biotechnol. 2022 Dec 2;10:1071472. doi: 10.3389/fbioe.2022.1071472. eCollection 2022.
Stem cell-based tissue engineering approaches are promising for bone repair and regeneration. Periodontal ligament stem cells (PDLSCs) are a promising cell source for tissue engineering, especially for maxillofacial bone and periodontal regeneration. Many studies have shown potent results PDLSCs in bone regeneration. In this review, we describe recent cutting-edge researches on PDLSC-based bone regeneration and periodontal tissue regeneration. An extensive search of the literature for papers related to PDLSCs-based bioactive constructs for bone tissue engineering was made on the databases of PubMed, Medline and Google Scholar. The papers were selected by three independent calibrated reviewers. Multiple types of materials and scaffolds have been combined with PDLSCs, involving xeno genic bone graft, calcium phosphate materials and polymers. These PDLSC-based constructs exhibit the potential for bone and periodontal tissue regeneration. In addition, various osteo inductive agents and strategies have been applied with PDLSCs, including drugs, biologics, gene therapy, physical stimulation, scaffold modification, cell sheets and co-culture. This review article demonstrates the great potential of PDLSCs-based bioactive constructs as a promising approach for bone and periodontal tissue regeneration.
基于干细胞的组织工程方法在骨修复和再生方面具有广阔前景。牙周膜干细胞（PDLSCs）是组织工程中一种很有前景的细胞来源，尤其适用于颌面部骨和牙周组织再生。许多研究表明PDLSCs在骨再生方面取得了显著成果。在这篇综述中，我们描述了基于PDLSCs的骨再生和牙周组织再生的最新前沿研究。我们在PubMed、Medline和谷歌学术数据库中广泛搜索了与基于PDLSCs的骨组织工程生物活性构建体相关的论文。这些论文由三位独立校准的评审员进行筛选。多种类型的材料和支架已与PDLSCs相结合，包括异种骨移植、磷酸钙材料和聚合物。这些基于PDLSCs的构建体展现出骨和牙周组织再生的潜力。此外，多种骨诱导剂和策略已应用于PDLSCs，包括药物、生物制剂、基因治疗、物理刺激、支架修饰、细胞片和共培养。这篇综述文章表明基于PDLSCs的生物活性构建体作为一种有前景的骨和牙周组织再生方法具有巨大潜力。
