铜催化的炔基羧酸与亚磺酸的脱羧二磺化反应。
Copper-Catalyzed Decarboxylative Disulfonylation of Alkynyl Carboxylic Acids with Sulfinic Acids.
机构信息
Faculty of Life Science and Technology, Kunming University of Science and Technology , Kunming 650500, People's Republic of China.
出版信息
Org Lett. 2018 Jan 19;20(2):489-492. doi: 10.1021/acs.orglett.7b03922. Epub 2018 Jan 9.
A copper-catalyzed decarboxylative disulfonylation of alkynyl carboxylic acids with sulfinic acids in aqueous solution has been developed. The reaction provides a straightforward and practical access to (E)-1,2-disulfonylethenes, which are important building blocks in synthetic organic chemistry, and exhibits a good functional group tolerance and excellent stereoselectivity. A possible mechanism for the transformation is proposed.
发展了一种在水溶液中铜催化的炔基羧酸与亚磺酸的脱羧二磺酰化反应。该反应为（E）-1,2-二磺酰乙烯提供了一种直接而实用的合成方法，（E）-1,2-二磺酰乙烯是合成有机化学中的重要构建块，并且具有良好的官能团耐受性和优异的立体选择性。提出了一种可能的转化机制。
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