Tambe Neal A, Wilkens Lynne R, Wan Peggy, Stram Daniel O, Gilliland Frank, Park S Lani, Cozen Wendy, Martínez-Maza Otoniel, Le Marchand Loic, Henderson Brian E, Haiman Christopher A
Am J Epidemiol. 2015 Jun 1;181(11):889-97. doi: 10.1093/aje/kwu361. Epub 2015 Apr 8.
Studies have provided evidence of an inverse association between atopic allergic conditions (AACs) and invasive colorectal cancer (CRC) incidence and mortality in predominantly white populations. We examined the association between AACs (asthma, hay fever, or allergy) and CRC among white, African-American, Native Hawaiian, Japanese-American, and Latino men and women in the Multiethnic Cohort Study within Hawaii and Los Angeles, California. The prospective analysis included 4,834 incident CRC cases and 1,363 CRC-related deaths ascertained between 1993 and 2010. We examined associations by ethnicity, location, stage, and potential effect modification by CRC risk factors. AACs were associated with a reduced risk of CRC incidence among both men and women (relative risk (RR) = 0.86, 95% confidence interval (CI): 0.80, 0.92). The reduction in risk was noted in all populations except Latinos and was significant in whites (RR = 0.85, 95% CI: 0.73, 0.98), African Americans (RR = 0.81, 95% CI: 0.70, 0.95), Native Hawaiians (RR = 0.72, 95% CI: 0.54, 0.96), and Japanese Americans (RR = 0.87, 95% CI: 0.78, 0.98). Individuals with AACs also had a 20% reduction in CRC-related mortality (P = 0.001). These findings provide evidence for the potential protective role of the reactive immune system in colorectal cancer.
研究已证实，在以白人为主的人群中，特应性过敏疾病（AACs）与浸润性结直肠癌（CRC）的发病率及死亡率呈负相关。我们在夏威夷和加利福尼亚州洛杉矶的多民族队列研究中，调查了白人、非裔美国人、夏威夷原住民、日裔美国人和拉丁裔男性及女性中AACs（哮喘、花粉症或过敏）与CRC之间的关联。前瞻性分析纳入了1993年至2010年间确诊的4834例新发CRC病例和1363例CRC相关死亡病例。我们按种族、地点、分期以及CRC风险因素的潜在效应修正来研究关联。AACs与男性和女性CRC发病率降低相关（相对风险（RR）=0.86，95%置信区间（CI）：0.80，0.92）。除拉丁裔外，所有人群均观察到风险降低，在白人（RR = 0.85，95% CI：0.73，0.98）、非裔美国人（RR = 0.81，95% CI：0.70，0.95）、夏威夷原住民（RR = 0.72，95% CI：0.54，0.96）和日裔美国人（RR = 0.87，95% CI：0.78，0.98）中具有显著性。患有AACs的个体CRC相关死亡率也降低了20%（P = 0.001）。这些发现为反应性免疫系统在结直肠癌中的潜在保护作用提供了证据。
