Eichenfield Lawrence F, Paller Amy S, Tom Wynnis L, Sugarman Jeffrey, Hebert Adelaide A, Friedlander Sheila Fallon, Siegfried Elaine, Silverberg Nanette, Cordoro Kelly M
Department of Dermatology, University of California, San Diego School of Medicine and Rady Children's Hospital, San Diego, CA, USA.
Department of Pediatrics, University of California, San Diego School of Medicine and Rady Children's Hospital, San Diego, CA, USA.
Pediatr Dermatol. 2018 Mar;35(2):170-181. doi: 10.1111/pde.13382. Epub 2018 Jan 4.
BACKGROUND/OBJECTIVES: Childhood-onset psoriasis is a common skin disorder that has recently received increasing attention, particularly because of its significant medical, social, financial, and psychological burdens and its associated comorbidities. With limited data available and lack of standardized management guidelines for pediatric psoriasis, an expert panel desired to provide an updated critical overview and practical guidance for management of the affected population.
A panel of pediatric dermatologists with extensive experience in pediatric psoriasis defined and prioritized a core set of topics, performed an English-language literature review, prepared critical evaluations and presentations of topic areas, and carried out a consensus meeting and follow-up consensus manuscript.
The summation of evolving perspectives in pediatric psoriasis includes epidemiology and natural history of the disease, precipitating factors and comorbidities, quality of life and burden of disease, clinical features and disease presentation, differential diagnosis, pathogenesis and treatment, including topical, photo, and systemic therapies.
Pediatric psoriasis is an important immune-mediated inflammatory skin disease with potential for significant impact on affected individuals and their caregivers. Current state-of-the-art care is based primarily on experience and expert consensus, but pediatric data are accumulating and therapeutic options are rapidly evolving.
背景/目的：儿童期发病的银屑病是一种常见的皮肤疾病，近来受到越来越多的关注，尤其是因其带来的重大医学、社会、经济和心理负担以及相关的合并症。由于关于儿童银屑病的数据有限且缺乏标准化的管理指南，一个专家小组希望为受影响人群的管理提供最新的批判性综述和实用指导。
一个在儿童银屑病方面有丰富经验的儿科皮肤科医生小组确定了一组核心主题并排出优先级，进行了英文文献综述，对各主题领域进行了批判性评估并做了报告，还召开了一次共识会议并撰写了后续的共识手稿。
儿童银屑病不断发展的观点总结包括该疾病的流行病学和自然史、诱发因素和合并症、生活质量和疾病负担、临床特征和疾病表现、鉴别诊断、发病机制和治疗，包括局部治疗、光疗和全身治疗。
儿童银屑病是一种重要的免疫介导性炎症性皮肤病，可能对受影响个体及其照料者产生重大影响。当前的最佳治疗主要基于经验和专家共识，但儿科数据正在积累，治疗选择也在迅速发展。
