Center for Eating Disorders Helmond, Mental Health Center Region Oost-Brabant, Wesselmanlaan 25a, Helmond, HA, 5707, The Netherlands.
Department of Medical and Clinical Psychology, Tilburg University, Warandelaan 2, P.O. Box 90153, Tilburg, LE, 5000, The Netherlands.
Int J Eat Disord. 2018 Feb;51(2):97-101. doi: 10.1002/eat.22817. Epub 2018 Jan 4.
Uric acid is best known for its role in gout-the most prevalent inflammatory arthritis in humans-that is also described as an unusual complication of anorexia nervosa (AN). However, beyond gout, uric acid could also be involved in the pathophysiology and psychopathology of AN, as it has many biological functions serving as a pro- and antioxidant, neuroprotector, neurostimulant, and activator of the immune response. Further, recent research suggests that uric acid could be a biomarker of mood dysfunction, personality traits, and behavioral patterns. This article discusses the hypothesis that uric acid in AN may not be a mere innocent bystander determined solely by AN behavior and its medical complications. In contrast, the relation between uric acid and AN may have evolutionary origin and may be reciprocal, where uric acid regulates some features and pathophysiological processes of AN, including weight and metabolism regulation, oxidative stress, immunity, mood, cognition, and (hyper)activity.
尿酸最广为人知的作用是在痛风中——这是人类最常见的炎症性关节炎，也被描述为神经性厌食症（AN）的一种罕见并发症。然而，除了痛风，尿酸也可能参与 AN 的病理生理学和精神病理学，因为它具有许多生物功能，作为一种抗氧化剂和促氧化剂、神经保护剂、神经刺激剂和免疫反应的激活剂。此外，最近的研究表明，尿酸可能是情绪功能障碍、人格特征和行为模式的生物标志物。本文讨论了这样一种假设，即在 AN 中，尿酸可能不仅仅是一个单纯的无辜旁观者，它不仅仅由 AN 的行为及其医疗并发症决定。相反，尿酸与 AN 之间的关系可能具有进化起源，并且可能是相互的，尿酸调节 AN 的一些特征和病理生理过程，包括体重和代谢调节、氧化应激、免疫、情绪、认知和（过度）活动。
