Department of Pediatric Dentistry, New York University College of Dentistry, New York, NY, USA.
Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA.
Int J Paediatr Dent. 2018 May;28(3):291-299. doi: 10.1111/ipd.12353. Epub 2018 Jan 5.
To evaluate the caries relapse rate for a cohort of 2- to 4-year-old children at high risk of early childhood caries when treated with an intensive fluoride varnish (FV) regimen.
Eighty paediatric patients were recruited. Forty of these patients were high risk and received the FV treatment (three applications within 2 weeks and additional applications at 1 and 3 months) during 2009-2010. Mutans streptococci (MS) levels in the saliva were evaluated during the treatment period. A comparative group of 40 children, selected from an electronic record search at the New York University College of Dentistry to be of similar age, gender, and ethnicity, but not at elevated risk for ECC, received the standard of care (semi-annual FV treatment). Detailed caries examination and treatment records were obtained for all patients from 2009 to 2014.
A significant reduction (P < 0.001) in MS levels was observed in the intensive FV treatment group at the 3-month visit compared with baseline. There was no effect of the intensive FV treatment on caries outcome in the anterior teeth, and the overall caries scores were significantly increased on the posterior teeth.
The intensive FV regimen appears insufficient to prevent caries relapse in children at high risk for caries.
评估一个高风险婴幼儿龋（ECC）队列在接受强化氟化物漆（FV）治疗后的龋齿复发率。
招募了 80 名儿科患者。其中 40 名患者为高风险患者，在 2009-2010 年期间接受了 FV 治疗（2 周内进行 3 次应用，并在 1 个月和 3 个月时进行额外应用）。在治疗期间评估唾液中的变形链球菌（MS）水平。从纽约大学牙科学院的电子记录搜索中选择了一个年龄、性别和种族相似的 40 名儿童的对照组，但没有 ECC 的高风险，接受了标准护理（每半年一次 FV 治疗）。从 2009 年到 2014 年，所有患者的详细龋齿检查和治疗记录均从电子病历中获得。
与基线相比，强化 FV 治疗组在 3 个月访视时 MS 水平显著降低（P<0.001）。强化 FV 治疗对前牙的龋齿结果没有影响，而后牙的总体龋齿评分显著增加。
强化 FV 方案似乎不足以预防高风险儿童的龋齿复发。
