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槲皮素和金丝桃苷作为成人人类内皮细胞衰老溶解剂的研究。

Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells.

作者信息

Hwang HyunTae V, Tran Darlene Thuy, Rebuffatti Michelle Nicole, Li Chin-Shang, Knowlton Anne A

机构信息

Molecular & Cellular Cardiology, Cardiovascular Division, Department of Internal Medicine, University of California-Davis, Davis, CA, United States of America.

Division of Biostatistics, Department of Public Health Sciences, University of California-Davis, Davis, CA, United States of America.

出版信息

PLoS One. 2018 Jan 9;13(1):e0190374. doi: 10.1371/journal.pone.0190374. eCollection 2018.

DOI:10.1371/journal.pone.0190374
PMID:29315311
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5760026/
Abstract

Previously, quercetin has been reported to be a senolytic, a drug that selectively removes senescent cells, in HUVECs. However, we found neither quercetin nor Q3G was effective as a senolytic for adult human endothelial cells.

摘要

此前，据报道槲皮素在人脐静脉内皮细胞（HUVECs）中是一种衰老细胞溶解剂，即一种能选择性清除衰老细胞的药物。然而，我们发现槲皮素和Q3G对成人内皮细胞均无衰老细胞溶解剂的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da67/5760026/f69f72a2e667/pone.0190374.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da67/5760026/2292d43f518a/pone.0190374.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da67/5760026/8b41bf5608fc/pone.0190374.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da67/5760026/4b2f0039a643/pone.0190374.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da67/5760026/f69f72a2e667/pone.0190374.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da67/5760026/2292d43f518a/pone.0190374.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da67/5760026/8b41bf5608fc/pone.0190374.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da67/5760026/4b2f0039a643/pone.0190374.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da67/5760026/f69f72a2e667/pone.0190374.g004.jpg

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