Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
Centre for Bone and Muscle Health, Brock University, St. Catharines, ON L2S 3A1, Canada.
Molecules. 2024 Nov 14;29(22):5359. doi: 10.3390/molecules29225359.
Obesity, a prevalent global health issue, arises from an imbalance between caloric intake and energy expenditure, leading to the expansion of adipose tissue and metabolic dysfunction. White adipose tissue (WAT) stores energy as lipids, while brown adipose tissue (BAT) plays a pivotal role in energy dissipation through adaptive thermogenesis. Recent research initiatives have focused on finding strategies to decrease adipogenesis and fat mass accumulation and increase thermogenesis. Finding chemicals with anti-obesity properties would be beneficial. Resveratrol, a polyphenolic compound abundantly found in the skin of grapes and red wine, possesses anti-oxidant, anti-inflammatory, anti-cancer, and anti-obesity properties. This literature review examines the effects of resveratrol on adipocytes in culture and adipose tissue in animal models of obesity. The existing evidence indicates that resveratrol may exert its anti-obesity effects by inhibiting adipogenesis, promoting the apoptosis of mature adipocytes, reducing lipid accumulation, and increasing thermogenesis. Further research utilizing animal and clinical studies is required to understand in detail the anti-obesity potential of resveratrol.
肥胖是一个普遍存在的全球健康问题，它是由于热量摄入和能量消耗之间的不平衡引起的，导致脂肪组织的扩张和代谢功能障碍。白色脂肪组织（WAT）将能量以脂肪的形式储存，而棕色脂肪组织（BAT）则通过适应性产热在能量消耗中起着关键作用。最近的研究重点是寻找减少脂肪生成和脂肪量积累以及增加产热的策略。寻找具有抗肥胖特性的化学物质将是有益的。白藜芦醇是一种在葡萄皮和红酒中大量存在的多酚化合物，具有抗氧化、抗炎、抗癌和抗肥胖的特性。本文献综述探讨了白藜芦醇对体外培养的脂肪细胞和肥胖动物模型中脂肪组织的影响。现有证据表明，白藜芦醇可能通过抑制脂肪生成、促进成熟脂肪细胞的凋亡、减少脂质积累和增加产热来发挥其抗肥胖作用。需要利用动物和临床研究进一步研究，以详细了解白藜芦醇的抗肥胖潜力。
