肝细胞癌中IVIM-DWI参数与VEGF和MMPs表达的相关性研究。
A correlative study between IVIM-DWI parameters and VEGF and MMPs expression in hepatocellular carcinoma.
作者信息
Yang Cui, Wei Xiao-Qin, Zheng Jing, Tao Yun-Yun, Gong Xue-Qin, Li Li, Li Zu-Mao, Yang Lin, Mao Qi, Zhou Mao-Ting, Zhang Xiao-Ming
机构信息
Medical Imaging Key Laboratory of Sichuan Province, Department of Radiology and Medical Research Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Department of Radiology, Panzhihua Central Hospital, Panzhihua, China.
出版信息
Quant Imaging Med Surg. 2023 Mar 1;13(3):1887-1898. doi: 10.21037/qims-22-271. Epub 2023 Jan 2.
BACKGROUND
Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death worldwide. Angiogenic factors may be valuable indices of tumor recurrence and treatment and potentially useful markers for predicting the response to antiangiogenesis therapy. Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are major drivers of tumor angiogenesis. Preoperatively predicting the expression of VEGF and MMPs is crucial for treating HCC. Intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) has been successfully used in the differential diagnosis of HCC, pathological grading, and treatment response evaluation. However, the correlations between IVIM-DWI parameters and VEGF and MMP expression have not been reported. This study provides a preliminary analysis of the correlation between IVIM-DWI parameters and the expression of VEGF, MMP-2, and MMP-9 to investigate the value of IVIM-DWI in the noninvasive evaluation of angiogenesis in HCC.
METHODS
IVIM-DWI was performed in 61 patients with HCC 1 week before they underwent surgical resection. VEGF, MMP-2, and MMP-9 expression was detected using immunohistochemistry staining. Spearman correlation analysis was used to analyze the correlations between the IVIM-DWI parameters and VEGF, MMP-2, and MMP-9 expression in HCC.
RESULTS
The fast apparent diffusion coefficient fraction () value was positively correlated with the expression of VEGF (P<0.001), MMP-2 (P=0.002), and MMP-9 (P<0.001). The fast apparent diffusion coefficient (*) was positively correlated with VEGF (P<0.001) and MMP-9 (P<0.001) expression but was not correlated with MMP-2 (P=0.659) expression. The apparent diffusion coefficient (ADC) and slow apparent diffusion coefficient () values were not significantly correlated with the expression of VEGF (P=0.103 and P=0.543, respectively), MMP-2 (P=0.596 and P=0.338, respectively), or MMP-9 (P=0.102 and P=0.660, respectively).
CONCLUSIONS
IVIM-DWI can be used to noninvasively evaluate angiogenesis in HCC.
背景
肝细胞癌（HCC）是全球癌症相关死亡的第四大常见原因。血管生成因子可能是肿瘤复发和治疗的重要指标，也是预测抗血管生成治疗反应的潜在有用标志物。血管内皮生长因子（VEGF）和基质金属蛋白酶（MMPs）是肿瘤血管生成的主要驱动因素。术前预测VEGF和MMPs的表达对于HCC的治疗至关重要。体素内不相干运动（IVIM）扩散加权成像（DWI）已成功用于HCC的鉴别诊断、病理分级和治疗反应评估。然而，IVIM-DWI参数与VEGF和MMP表达之间的相关性尚未见报道。本研究对IVIM-DWI参数与VEGF、MMP-2和MMP-9表达之间的相关性进行初步分析，以探讨IVIM-DWI在HCC血管生成无创评估中的价值。
方法
对61例HCC患者在手术切除前1周进行IVIM-DWI检查。采用免疫组织化学染色检测VEGF、MMP-2和MMP-9的表达。采用Spearman相关性分析IVIM-DWI参数与HCC中VEGF、MMP-2和MMP-9表达之间的相关性。
结果
快速表观扩散系数分数（）值与VEGF（P<0.001）、MMP-2（P=0.002）和MMP-9（P<0.001）的表达呈正相关。快速表观扩散系数（*）与VEGF（P<0.001）和MMP-9（P<0.001）的表达呈正相关，但与MMP-2（P=0.659）的表达无相关性。表观扩散系数（ADC）和慢速表观扩散系数（）值与VEGF（分别为P=0.103和P=0.543）、MMP-2（分别为P=0.596和P=0.338）或MMP-9（分别为P=0.102和P=0.660）的表达均无显著相关性。
结论
IVIM-DWI可用于无创评估HCC的血管生成。
Zotero 插件