• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

利福平：一种具有脑保护功能的抗生素。

RIFAMPICIN: an antibiotic with brain protective function.

作者信息

Yulug Burak, Hanoglu Lütfü, Kilic Ertugrul, Schabitz Wolf Rüdiger

机构信息

Department of Neurology, University of Istanbul-Medipol, Istanbul, Turkey.

Department of Neurology, University of Istanbul-Medipol, Istanbul, Turkey.

出版信息

Brain Res Bull. 2014 Aug;107:37-42. doi: 10.1016/j.brainresbull.2014.05.007. Epub 2014 Jun 4.

DOI:10.1016/j.brainresbull.2014.05.007
PMID:24905548
Abstract

Besides its well known antibiotic activity rifampicin exerts multiple brain protective functions in acute cerebral ischemia and chronic neurodegeneration. The present mini-review gives an update of the unique activity of rifampicin in different diseases including Parkinson's disease, meningitis, stroke, Alzheimer's disease and optic nerve injury.

摘要

除了其广为人知的抗生素活性外，利福平在急性脑缺血和慢性神经退行性变中发挥多种脑保护功能。本综述简要介绍了利福平在帕金森病、脑膜炎、中风、阿尔茨海默病和视神经损伤等不同疾病中的独特活性。

相似文献

1
RIFAMPICIN: an antibiotic with brain protective function.利福平：一种具有脑保护功能的抗生素。
Brain Res Bull. 2014 Aug;107:37-42. doi: 10.1016/j.brainresbull.2014.05.007. Epub 2014 Jun 4.
2
Natural products from marine organisms with neuroprotective activity in the experimental models of Alzheimer's disease, Parkinson's disease and ischemic brain stroke: their molecular targets and action mechanisms.在阿尔茨海默病、帕金森病和缺血性脑卒中等实验模型中具有神经保护活性的海洋生物天然产物：它们的分子靶点和作用机制。
Arch Pharm Res. 2015 Feb;38(2):139-70. doi: 10.1007/s12272-014-0503-5. Epub 2014 Oct 28.
3
New hope for mechanism-based treatment of Parkinson's disease.基于机制治疗帕金森病的新希望。
Drug Discov Today. 2005 Jan 15;10(2):80-1. doi: 10.1016/S1359-6446(04)03340-9.
4
Therapeutic role of rifampicin in Alzheimer's disease.利福平在阿尔茨海默病中的治疗作用。
Psychiatry Clin Neurosci. 2018 Mar;72(3):152-159. doi: 10.1111/pcn.12637. Epub 2018 Feb 10.
5
Rifampicin and Parkinson's disease.利福平与帕金森病。
Neurol Sci. 2013 Feb;34(2):137-41. doi: 10.1007/s10072-012-1156-0. Epub 2012 Jul 21.
6
Exploring the potential of natural and synthetic neuroprotective steroids against neurodegenerative disorders: A literature review.探索天然和合成神经保护类固醇治疗神经退行性疾病的潜力：文献综述。
Med Res Rev. 2018 Jul;38(4):1126-1158. doi: 10.1002/med.21458. Epub 2017 Jul 11.
7
A review on iron chelators as potential therapeutic agents for the treatment of Alzheimer's and Parkinson's diseases.铁螯合剂作为治疗阿尔茨海默病和帕金森病的潜在治疗药物的研究进展。
Mol Divers. 2019 May;23(2):509-526. doi: 10.1007/s11030-018-9878-4. Epub 2018 Oct 6.
8
[Research advance of the protective role of PACAP in the nervous system diseases].[垂体腺苷酸环化酶激活肽在神经系统疾病中保护作用的研究进展]
Sheng Li Ke Xue Jin Zhan. 2011 Aug;42(4):276-80.
9
Rifampicin inhibits neurodegeneration in the optic nerve transection model in vivo and after 1-methyl-4-phenylpyridinium intoxication in vitro.利福平在体内视神经横断模型以及体外1-甲基-4-苯基吡啶离子中毒后均能抑制神经退行性变。
Acta Neuropathol. 2004 Jul;108(1):65-8. doi: 10.1007/s00401-004-0867-6. Epub 2004 May 8.
10
Impacts of methylxanthines and adenosine receptors on neurodegeneration: human and experimental studies.甲基黄嘌呤和腺苷受体对神经退行性变的影响：人体及实验研究
Handb Exp Pharmacol. 2011(200):267-310. doi: 10.1007/978-3-642-13443-2_10.

引用本文的文献

1
Systemic inflammation as a central player in the initiation and development of Alzheimer's disease.全身炎症是阿尔茨海默病发生和发展的核心因素。
Immun Ageing. 2025 Aug 21;22(1):33. doi: 10.1186/s12979-025-00529-5.
2
Newer Therapeutic Approaches in Treating Alzheimer's Disease: A Comprehensive Review.治疗阿尔茨海默病的新型治疗方法：综述
ACS Omega. 2025 Feb 3;10(6):5148-5171. doi: 10.1021/acsomega.4c05527. eCollection 2025 Feb 18.
3
A review of the roles of pathogens in Alzheimer's disease.病原体在阿尔茨海默病中的作用综述。
Front Neurosci. 2024 Aug 19;18:1439055. doi: 10.3389/fnins.2024.1439055. eCollection 2024.
4
Nano-Medicine for Treatment of Tuberculosis, Promising Approaches Against Antimicrobial Resistance.纳米医学治疗结核病，对抗抗菌药物耐药性的有前景的方法。
Curr Microbiol. 2024 Aug 24;81(10):326. doi: 10.1007/s00284-024-03853-z.
5
Marine-derived Compounds: A Powerful Platform for the Treatment of Alzheimer's Disease.海洋来源化合物：治疗阿尔茨海默病的有力平台。
Cent Nerv Syst Agents Med Chem. 2024;24(2):166-181. doi: 10.2174/0118715249269050231129103002.
6
Blood-Brain Barrier Breakdown in Alzheimer's Disease: Mechanisms and Targeted Strategies.阿尔茨海默病中的血脑屏障破坏：机制与靶向策略。
Int J Mol Sci. 2023 Nov 14;24(22):16288. doi: 10.3390/ijms242216288.
7
State of the Art on Developments of (Bio)Sensors and Analytical Methods for Rifamycin Antibiotics Determination.利福霉素类抗生素检测用（生物）传感器和分析方法的最新进展。
Sensors (Basel). 2023 Jan 14;23(2):976. doi: 10.3390/s23020976.
8
The Interplay between Gut Microbiota and Parkinson's Disease: Implications on Diagnosis and Treatment.肠道微生物群与帕金森病的相互作用：对诊断和治疗的影响。
Int J Mol Sci. 2022 Oct 14;23(20):12289. doi: 10.3390/ijms232012289.
9
Targeted brain delivery of RVG29-modified rifampicin-loaded nanoparticles for Alzheimer's disease treatment and diagnosis.用于阿尔茨海默病治疗与诊断的RVG29修饰的载利福平纳米颗粒的靶向脑递送。
Bioeng Transl Med. 2022 Aug 26;7(3):e10395. doi: 10.1002/btm2.10395. eCollection 2022 Sep.
10
Insights into the roles of bacterial infection and antibiotics in Parkinson's disease.细菌感染和抗生素在帕金森病中的作用的研究进展。
Front Cell Infect Microbiol. 2022 Jul 28;12:939085. doi: 10.3389/fcimb.2022.939085. eCollection 2022.