Russian National Centre of Surgery, Avtsyn Research Institute of Human Morphology, Moscow, 117418, Russia.
Pirogov Russian National Research Medical University (RNRMU), Moscow, 117997, Russia.
Eur J Appl Physiol. 2024 Jun;124(6):1631-1643. doi: 10.1007/s00421-024-05496-1. Epub 2024 Apr 29.
The gut microbiota plays an important role in maintaining human health and in the pathogenesis of several diseases. Antibiotics are among the most commonly prescribed drugs and have a significant impact on the structure and function of the gut microbiota. The understanding that a healthy gut microbiota prevents the development of many diseases has also led to its consideration as a potential therapeutic target. At the same time, any factor that alters the gut microbiota becomes important in this approach. Exercise and antibacterial therapy have a direct effect on the microbiota. The review reflects the current state of publications on the mechanisms of intestinal bacterial involvement in the pathogenesis of cardiovascular, metabolic, and neurodegenerative diseases. The physiological mechanisms of the influence of physical activity on the composition of the gut microbiota are considered. The mechanisms of the common interface between exercise and antibacterial therapy will be considered using the example of several socially important diseases. The aim of the study is to show the physiological relationship between the effects of exercise and antibiotics on the gut microbiota.
肠道微生物群在维持人类健康和多种疾病的发病机制中起着重要作用。抗生素是最常用的药物之一，对肠道微生物群的结构和功能有重大影响。人们认识到健康的肠道微生物群可以预防许多疾病，因此也将其视为一种潜在的治疗靶点。与此同时，任何改变肠道微生物群的因素在这种方法中都变得很重要。运动和抗菌治疗对微生物群有直接影响。该综述反映了目前关于肠道细菌参与心血管、代谢和神经退行性疾病发病机制的出版物状况。考虑了身体活动对肠道微生物群组成影响的生理机制。将使用几种社会重要疾病的例子来考虑运动和抗菌治疗之间常见界面的机制。本研究的目的是展示运动和抗生素对肠道微生物群的影响的生理关系。
