NHMRC Centre for Excellence in Severe Asthma, Newcastle, NSW, Australia.
Department of Respiratory Medicine, Royal North Shore Hospital, Sydney, NSW, Australia.
Respirology. 2018 Mar;23(3):262-271. doi: 10.1111/resp.13251. Epub 2018 Jan 9.
Severe asthma is defined by the high treatment requirements to partly or fully control the clinical manifestations of disease. It remains a problem worldwide with a large burden for individuals and health services. The key to improving targeted treatments, reducing disease burden and improving patient outcomes is a better understanding of the pathophysiology and mechanisms of severe disease. The heterogeneity, complexity and difficulties in undertaking clinical studies in severe asthma remain challenges to achieving better understanding and better outcomes. In this review, we focus on the structural, mechanical and inflammatory abnormalities that are relevant in severe asthma.
严重哮喘的定义是需要高治疗要求来部分或完全控制疾病的临床表现。它仍然是一个全球性的问题，给个人和卫生服务带来了巨大的负担。改善靶向治疗、减轻疾病负担和改善患者预后的关键是更好地了解严重疾病的病理生理学和发病机制。严重哮喘的临床研究中的异质性、复杂性和困难仍然是实现更好理解和更好结果的挑战。在这篇综述中，我们重点介绍了与严重哮喘相关的结构、机械和炎症异常。
